壳聚糖对小儿解表止咳口服液澄清效果的影响-中国药房.PDF

壳聚糖对小儿解表止咳口服液澄清效果的影响 1＊ 1 2 2 张俊侠 ，魏灿英 ，焦小珂 ，肖 禾 （1.成都大学医护学院，成都 611137；2. 四川广元蓉成制药有限公司，四 川广元 628000） 中图分类号 R284.2；R283 文献标志码 A 文章编号 1001-0408（2014）15-1389-03 DOI 10.6039/j.issn. 1001-0408.2014.15.15 摘 要 目的：建立用壳聚糖提高小儿解表止咳口服液澄明度的方法。方法：采用壳聚糖的絮凝作用对小儿解表止咳口服液进行 处理。采用单因素试验和正交试验考察壳聚糖用量、澄清温度、澄清时间对有效成分盐酸麻黄碱质量浓度的影响，并与传统的醇 沉法相比较。结果：最佳澄清工艺为1％壳聚糖溶液用量为15％，澄清温度为80 ℃，澄清时间为24h ；用壳聚糖絮凝法处理的小儿 解表止咳口服液澄明度优于醇沉法，但提取的盐酸麻黄碱的质量浓度无明显差异。结论：壳聚糖絮凝法准确、简便、重现性好、成 本低廉，可明显改善小儿解表止咳口服液的澄明度。 关键词 小儿解表止咳口服液；壳聚糖；澄明度；正交试验 Effects of Chitosan on the Clarification of JBZK Oral Liquid 1 1 2 2 ZHANG Jun-xia ，WEI Can-ying ，JIAO Xiao-ke ，XIAO He （1.Medical and Nursing School ，Chengdu Universi- ty ，Chengdu 611137，China ；2.Sichuan Guangyuan Rongcheng Pharmaceutical Co. ，Ltd. ，Sichuan Guangyuan 628000，China ） ABSTRACT OBJECTIVE ：To establish a method of improving the clarity of JBZK oral liquid by using chitosan. METHODS ： JBZK oral liquid was treated with flocculation effect of chitosan. Single factor test and orthogonal experiment were adopted to inves- tigate the effects of different amount of chitosan ，clarification temperature and clarification time on the concentration of ephedrine hydrochloride ，and then compared with the water extraction and alcohol precipitation method. RESULTS ：The optimal flocculation technology was as follows ：15％dose of 1％chitosan ，clarification temperature at 80 ℃and clarification time of 24h. The clarity of the JBZK oral liquid treated by chitosan flocculence method was better than treated by alcohol precipitation method. The contents of ephedrine hydrochloride had no significant difference between 2 methods. CONCLUSIONS ：The chitosan flocculence method is accurate ，simple ，reproducible and cheap ，and can improve the clarity of JBZK oral liquid. KEYWORDS JBZK oral liquid