热休克蛋白60的研究进展.PDF

中国病理生理杂志 　Chinese Journal of Pathophysiology 　2004 ,20 ( 11) :2151 - 2154 ·2 15 1 · ( ) [文章编号] 　1000 - 4718 2004 11 - 2151 - 04 热休克蛋白60 的研究进展 龚兴国 , 　于 　红 (浙江大学生命科学学院 , 浙江 杭州 310027) Recent advances in heat shock protein 60 GON G Xing - guo , YU Hong ( Dep artment of B iochemistry , Academy of L fi e Sciences of Zhej iang University , Hangz hou 310027 , China) 　　【A Revie w】　The family of HSP60 belongs to heat shock proteins with highly species conservatism and some important biologic functions. It can help other proteins for their assembling , folding and translocating , and plays a role in protecting cells against inj uries and other types of stress. In addition , HSP60 is frequently recog nized by the immune system as predominant antigens during infections and the progression of certain autoimmune diseases and might provide a novel strategy for the development of immunotherapeutics. This review focuses on distribution , molecular chaperone mechanism , function and gene expression regulation of HSP60 . 　　[ 关键词] 　监控蛋白60 ; 免疫疗法 　　[ KEY WORDS] 　Chaperonin 60 ; Immunotherapy 　　[ 中图分类号] 　R363 　　　　　[文献标识码] 　A 　　热休克蛋白是高水平基础表达的一种蛋 白, 占 似物是大肠杆菌的伴侣蛋白 GroEL ,而在真核生物的 在正常生长条件下所有类型细胞中蛋白总量的 5 % 线粒体中以 HSP60 形式存在 ,高等植物叶绿体中的 ( - 10 % 。当细胞处于应激条件时 如重金属 、热休 HSP60 是二磷酸核酮糖羧化酶固氧酶亚基的结合蛋 ( ) 克 、周围气温的变化 、糖分损失 、游离 自由基的作用 、 白 rubisco binding protein , RBP , RBP 与 GroEL 和线 ) β 病原体传染 、组织损伤 、精