认知康复训练治疗精神分裂症认知功能障碍的对照研究.docxVIP

认知康复训练治疗精神分裂症认知功能障碍的对照研究赵玮琳陶建青尹雪冰曾强石捷(广西壮族自治区人民医院心理康复中心广西南宁530021)【摘要】目的探讨认知康复训练对精神分裂症患者认知功能障碍的影响。方法将服用第一代抗精神病药物有认知功能障碍的精神分裂症患者80例随机分为研究组与对照组各40例，研究组联合认知康复训练，对照组合用毗拉西坦。分别于治疗前、治疗后12周进行阳性与阴性症状量表(PANSS)、数字广度测验(DS)、语词流畅性测验(VF)、钉板实验(GPT)、连线试验A (TMT-A)及威斯康星卡片分类测验(WCST)评估。结果研究组治疗后PANSS、GPT、TMT-A、Ra、Rpe 下降，DS、VF、Cc Rc 提高(P0.05 或PV0.01)；对照组治疗后DS、VF、Rc比治疗前提高(P0.05或P0.01), Rpe下降(PV0.05)。治疗后研究组GPT、TMT-A以及Ra、Cc、Rc、Rpe评分均优于对照组(P0.05或PV0.01)。结论认知康复训练与毗拉西坦均可改善精神分裂症患者的认知功能，认知康复训练疗效优于毗拉西坦。【关键词】精神分裂症认知功能认知康复训练毗拉西坦【中图分类号】R493【文献标识码】A【文章编号】2095-1752 (2013) 35-0011-02[Abstract] Objective To explore the effect of cognitive rehabilitation training on cognitive dysfunction in patients with schizophrenia. Method Eighty cognitive dysfunction patients with schizophrenia who took the first-generation antipsychotic drugs were randomly divided into study group and control group with 40 cases in each, the study group was combined with cognitive rehabilitation training, the control group was combined with piracetam. Positive and Negative Syndrome Scale(PANSS),Digit Span Test(DS),Verbal Fluency Test(VF), Grooved Pegboard Test(GPT), Trail Making Test-A仃MT?A) and Wisconsin Card Sorting Test(WCST) wereassessment before and after 12 weeks treatmentjespectively.Results The scores ofPANSS, GPT, TMT-A, Ra, Rpe in the study group after treatment were decreased, DS, VF, Cc, Rc were increased (Plt;0.05orPlt;0.01); the scores of DS, VF, Rc in the con trol group after treatme nt were in creased compared with before treatment(Plt;0.05orPlt;0.01), Rpe was decreased (Plt;0.05). After treatment, The scores of GPT7TMT?A,Ra，Cc, Rc, Rpe in study group were better than the control group (Plt;0.05orPlt;0.01). Conclusion Cognitive rehabilitation training and piracetam can improve cognitive function in schizophrenia, but cognitive rehabilitation training is better than piracetam.【Key words］ Schizophrenia Cognitive function Cognitive rehabilitation training Piracetam.精神分裂症是一种常见口严重的精神障碍，给患者、家庭、社会造成沉重负担⑴。抗精神病药物控制幻觉妄想等精神病性症状，