课件：深部真菌感染诊断.pptVIP

疑诊侵袭性肺部真菌感染 IFI的诊断标准 invasive fungous infections 级别 宿主因素 临床特征 微生物学 组织病理学 确诊（proven） ± + + △ + 临床诊断（probable） + + + _ 临床拟诊（possible） + + _ _ 注：﹢有﹣无 △肺组织、胸液、血液真菌培养阳性（除肺孢子菌外） 确诊 1. 艾滋病（AIDS） 2. 马尼菲青霉菌肺部感染 3. 马尼菲青霉菌败血症 确诊后治疗 5-21 　两性霉素B 1mg 5-22 　3mg 5mg 5-23 　10mg 15mg 5-24 　25mg 5-23 　加用伊曲康唑 0.2 bid 至5-24体温降至正常 深部真菌感染 SFI IFI 增强意识 提高认识 NOTICE THANK YOU SUCCESS * * 可编辑 * * Above are antifungals which target the cell membrane. First of all we will look at the azole family. These drugs are far less toxic than amphotericin B. * Flucytosine is an anti-metabolite type of antifungal drug. It is a synthetic fluorinated pyrimidine which is available for intravenous infusion or oral administration. It is marketed as Ancotil. * Echinocandins are highly active against a number of Candida species, with Candida parapsilosis and Candida gulliermondii having a higher MIC. In vitro killing of these species is very rapid. No activity was seen vs Zygomycetes, Cryptococcus neoformans, Fusarium spp and Trichosporon sp. * Echinocandins are highly active against a number of Candida species, with Candida parapsilosis and Candida gulliermondii having a higher MIC. In vitro killing of these species is very rapid. No activity was seen vs Zygomycetes, Cryptococcus neoformans, Fusarium spp and Trichosporon sp. * 折点是综合了体外MIC值及体内血药有效并安全的浓度，制定出S,S-dd〔或I〕,R * * The immunogenic properties of fungal organisms have been exploited in tests for the presence of both fungal antigen and antibody in biologic fluids. The diagnostic value of tests for antigen or antibody reactions is highly dependent on the organism. Numerous methodologies have been used or are being developed with varying degrees of sensitivity and specificity. These include counter-immunoel