吉西他滨灌注治疗腺性膀胱炎的初步分析-外科学(泌尿外科学)专业论文.docxVIP

新疆医科大学硕士学位论文 新疆医科大学硕士学位论文 PAGE PAGE 1 吉西他滨灌注治疗腺性膀胱炎的初步研究 研究生：张健 导师：木拉提·马合木提副教授 摘 要 目的：探讨吉西他滨在治疗腺膀胱炎中的应用。方法：对新疆医科大学第二附 属医院 2006 年 6 月至 2010 年 12 月收治的 41 例腺性膀胱炎患者的临床资料床资料 进行回顾性分析，对 41 例病例行经尿道电切或电灼术，术后 20 例行膀胱灌注，21 例因各种原因未能行膀胱灌注，根据术后患者是否坚持吉西他滨膀胱灌注分为联合 组和单纯手术组，对不同组别患者治疗的疗效进行统计学分析。结果：本组病例主 要临床症状为尿频尿急尿痛等下尿路刺激症状，镜下或是肉眼血尿，所有病例均行 膀胱镜检查并送病理检查确诊为腺性膀胱炎，均行经尿道电切或是电灼术，联合组 术后 1-2 天开始行第一次吉西他滨膀胱灌注治疗，每周一次，六次后改为两周一次， 总共灌注八次，对照组因为各种原因未能行膀胱灌注。联合组：有效 19 例，无效 1 例，有效率为 90.0%；对照组：有效 13 例，无效 8 例，有效率为 61.9% 应用 SPSS17.0 进行统计处理。得 P＜0.05，差别有统计学意义，联合组疗效优于对照组。术后两 组患者不良反应发生率较低，无明显并发症发生，无患者因不良反应而停止药物灌 注，不影响疗程的进行。结论：经尿道电切或电灼术联合术后吉西他滨膀胱内灌注 是治疗腺性膀胱炎一种新的有效方法。 关键词：腺性膀胱炎；电切术；吉西他滨 A new research of gemcitabine intravesical irrigation for the treatment of cystitis glandularis Postgraduate:Zhang Jian Supervisor: Ass Prof. Mulati·Mahemuti Abstract Objective: To study the effect of gemcitabine in the treatment of cystitis glandularis. Methods:Data of clinical 41 cases were analyzed retrospectively during Jun. 2006 to Nov. 2010 in the Second Hospital Affiliated to Xinjiang Medical University. The clinical data of 41 cases were divided into two groups. One combined group of 20 cases was treated by transurethral electro-resection combined with bladder instillation of gemcitabine. The other investigation group of 21 cases was treated by transurethral electro-resection as the sole modality. Effects on different group of patients were compared. Results:All patients were diagnosed cystitis glandularis using the biopsy by cystoscope. The main sympotm of the group is urinary frequency , urgency , odynuria and hematuria. One or two days after the surgery , the patients were treated by bladder instillation of gemcitabine once a week. 6 weeks later , the patients were treated by instillation every two week. There were 8 times in total. There are no complications , no patients discontinued due to adverse events. The combined group:19 cases were effective , 1 cases were ineffective. T