急性脑血管病凝溶指标变化的临床研究-神经病学专业论文.docxVIP

i590．47急性脑血管病凝溶指标变化的临床研究 i590．47 急性脑血管病凝溶指标变化的临床研究 巾文摘要 中文摘要 目的：本研究目的是探讨急性期脑出血、腔隙性脑梗死的凝血、 纤溶功能变化规律，为临床治疗提供理论依据。 ／方法脑出血组37例，男21例，女16例。平均年龄63．5岁： 腔隙性脑梗死36例，男19例，女17例，平均年龄67．3岁：健康对 照组35人，男20例，女15例，平均年龄60．1岁。对照组、实验组 均除外有糖尿病、肝病史及血液病。采用ELISA方法测定：t-PA、 PAl．1、PC及D．dimer血浆含量：采用凝固法测定：Fib；采用免疫 浊度法测定：AT．Ⅲ含量。试剂盒购自上海太阳生物技术公司。)～ 结果脑出血组、腔梗组的t-PA浓度高于对照组(P0．001=； 脑出血组PAl．1浓度低于对照组(P=0．01)；脑出血组PC浓度高于 对照组(Po．001=；脑出血组、腔梗组D—dimer浓度高于对照组 (P=0．们、P=0．09)；脑出血组、腔梗组的AT一Ⅲ浓度均低于对照组 (P0．001=；脑出血组、腔梗组Fib浓度均低于对照组(P0．001 =o 结论急性脑出血患者有抗凝功能异常，脑出血急性期t-PA和 PAl．1变化规律不同于缺血性脑血管病。腔隙性脑梗死急性期t-PA 和PAl．1变化不同于大面积脑梗死。 关键词 急性脑血管病；脑出血；腔隙性脑梗死；凝血；纤溶 叁丝堕皇篁塑鳖苎塑堡窒堡塑堕堕堑塞 叁丝堕皇篁塑鳖苎塑堡窒堡塑堕堕堑塞 一一——垒坠!!!竺 The change of coagulative，fibrinolytic markers and the clinicaI research in acute cerebrovascular diseases Abstract objective To investigate the characteristic change of the hemostatic and fibrinolytic markers in patients with acute intracerebral hemorrhage(ICH)and lacunar infarct(ICI)and get theory foundation for treatment． Methods A series of hemostatic and fibrinolytic parameters were measured mnong 37 cases of ICH and 36 cases of ICI by using ELISA or coagulative and flocculent immunoassay．The parameters include t-PA，PAl一1， PC，D-dimer,AT-III，Fib．Meanwhile，thirty-five age-and sex-matched healthy subjects are tested aS con仃ol group． ● } Resuits Plasma 1evel of t-PA iS elevated significantly in ICH and ICI cases．(P0．001)．In ICH cases，the level of PAI．1iS lower and PC is highel’in significance(P=0．01，PO．001)The plasma level of D—dimer in ICH and ICI is elevated，matched as control group． (P=O．01．P=O．09)．The levels of AT．III and Fib in ICH and ICI are Iower significantly than those in control cases． Conclusion There are the hemostatic abnormalities in acute intracerebral hemorrhage．The changeable law of level of t-PA and PAI-1 are significantly different between hemorrhagic and ischemic stroke．Those changeable laws are significantly different between lacunar and ischemic infarct。 Keywords cerebrovascular,disease， acute，coagula