马鞭草苷对大、小鼠慢性非细菌性前列腺炎模型影响的研究-中药学专业毕业论文.docxVIP

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马鞭草苷对大、小鼠慢性非细菌性前列腺炎模型影响的研究-中药学专业毕业论文.docx

马鞭草苷对大、小鼠慢性非细菌性前列腺炎模型影响的研究 马鞭草苷对大、小鼠慢性非细菌性前列腺炎模型影响的研究 英文摘要 英文摘要 PAGE PAGE 10 PAGE PAGE 11 TNF-α水平显著升高(P﹤0.01);模型组大鼠前列腺体密度(Vv)显著增大(P ﹤0.01)。与模型组相比,马鞭草苷高剂量、中、低剂量组大鼠前列腺指数显著降 低(P﹤0.01);前列腺液中白细胞数显著降低( P﹤0.01),卵磷脂小体密度积分 显著增加(P﹤0.01);前列腺匀浆中 IL-2、IL-1β、TNF-α水平显著或明显降低 (P﹤0.01 或 P﹤0.05);前列腺体密度(Vv)显著降低(P﹤0.01),前列腺炎症 的病理改变显著减轻(P﹤0.01);马鞭草苷高剂量组胸腺皮质显著增厚(P﹤0.01), 淋巴细胞个数显著增多(P﹤0.01)。 结论:马鞭草苷具有抑制模型动物前列腺炎的作用。可显著改善前列腺炎症 状,降低前列腺指数,减少前前列腺组织和列腺液中白细胞数,增加卵磷脂小体 密度评分,降低 IL-2、IL-1β、TNF-α水平,抑制炎症浸润和纤维组织增生, 增强免疫功能,逆转病理过程,从而对慢性前列腺炎起到治疗作用。 关键词:马鞭草苷;慢性非细菌性前列腺炎;模型 Studies on the Effect of Verbenalin on the Animal Model of Prostatitis Wan g Linli n ( Tra dit ional Chi nese M ateri a M edi ca ) Direct ed b y Mi ao Mi n gs an Abstract Obj ectiv es : To obs erve th e effect and mech ani sm o f Verben ali n o n treati n g t h e rat ’s and mo us e’s P rost ati tis mo del th rou gh measu rin g th e pro stat e in dex ,th e nu mber of W BC an d lecithi n bod y t he l ev el of IL-2 、 IL-1 β and TN F -α , and o bservi n g t he mi croco smic chan ge o f relat ed t issu es . Meth ods :Th e mi ce Prost atiti s mo del s were es tablish ed b y i nj ectin g 25 % hemo rrhoi d inj ect ion in th e rats and mice prost ate. From th e ei ghth d a y o f model-m aki n g, th e rats and mi ce of th e Q IANLIE KANG gro up were d ren ch ed QIAN LIE K AN G TA BLE TS susp en sion , t he rats and mice o f t he h i gh , mid dle and l ow d os age of V erbenalin grou ps were dren ch ed Verb en alin sus pensio n, the rats an d mi ce o f t he no rmal grou p and the m od el gro up were fill ed n ormal salin e i nto th e sto machs. D ru g was d renched o nce a d a y. Meas uri n g t he drin kin g w at er qu ant um o f ev er y mo us e grou p at th e du e d a y. On t he 21 th d a y aft er t h e mi ce t ak in g m edi cin e, m easu ri n g prost ate tis su e W BC and lecit hin bulk d en sit y s co re, t he mi cro cosmi c ch an ge o f rel at ed ti ssu es . On th e 2 2 th da y aft er th e rats t aki n g medi cin e

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