血脂水平与冠状动脉内支架术后再狭窄的关系.doc

2008 届临床七年制硕士研究生毕业论文 The relationship between serum-cholesterol and intracoronary in-stent restenosis ABSTRACT The Background and purpose : Gruentzig carried on the first case of the percutaneous transluminal coronary angioplasty (PTCA) in 1977 Hereafter in more than 20 years percutaneous coronary intervention (PCI) has gotten rapid development In the development of PCI the critical problem we are facing is the high rate of restenosis happening 6 months after operation,which is about 30-50% So our main concern is now on the pathophysiological mechanism of this course To evaluate the relationship between serum-cholesterol and intracoronary in-stent restenosis during angiographic follow-up we study and research the affective factor though 370 cases who have accepted the second coronary artery angiography in our hospital from 2001-5 2006-10 by the method of QCA 4 2008 届临床七年制硕士研究生毕业论文 Methods : 370 patients who were implanted stent in coronary artery and reangiographied in our hospital from 2001-5 2006-10 were selected in our investigation There were 94 cases with in-stent restenosis and 276 cases without in-stent restenosis All cases were divided into two groups according to the result of angiography if there was restenosis The definition of restenosis is within 5mm outside from the stent. The reference vessles are the normal blood vessel farside the lesion The radiography machine is VOC digital subtraction angiography(DSA) from GE company in American The operation method was the method of Judkin’ s puncture through right femoral artery The diseased vessels were photographed by left anterior oblique and cranial, post-anterior and caudal left and lateral, right and lateral position. According to dividing the case into restenosis group(n=94) and without restenosis group(n=276) then compared dangerous factors,characteristic of lesions of two groups analysed the data with software of SAS6 12 The data of numerical variable were analysed with t-test the data of categorical v