血清CA125对卵巢癌的诊断价值及与临床分期的相关性研究.docVIP

血清CA125对卵巢癌的诊断价值及与临床分期的相关性研究 王小玉 (安徽省六安市人民医院妇产科 237005) 【摘要】目的 观察CA125、CA19-9、CA72-4在卵巢癌患者中的诊断价值，分析 CA125水平与卵巢癌临床分期之间的相关性。方法 采用电发光法检测63例卵 巢癌及60例卵巢良性肿瘤患者血清CA125、CA19-9 CA72-4水平。结果 联合 检测血清CA125CA19-9CA72-4的敏感性及特异性显箸高于单项检测(Plt;0.05)； 随着临床分期的增加，血清CA125水平逐渐升高。结论 联合检测血清CA125、 CA19-9. CA72-4对卵巢癌的诊断和鉴别诊断具有重要价值，值得临床推广应用； CA125对卵巢癌的病情评估具有重要指导作用。 【关键词】卵巢癌CA125 CA19-9 CA72-4联合检测临床分期 【中图分类号】R730.4 【文献标识码】A 【文章编号】2095-1752 (2013) 21-0120-02 An alysis of the diag no Stic value of the serum CA125 in ovaria n carci noma and the relati on ship betwee n it and clin ical stage of ovarian carcinoma. 【Abstract 】 Objective To explore the significanee of serum CA125, CA19-9 and CA72-4 in diagnosis of ovaria n carci no ma; To in vestigate the relationship betwee n the serum CA125 and the clin ical stage of ovarian carci no ma. Methods The serum levels of CA125, CA19-9 and CA72-4 of 63 patients with ovarian carcinoma, 60 patients with benign ovarian tumor were detected by electrochemical method. Results The sensitivity and specificity of CA125, CA19-9 and CA72-4 combined detection was higher than that of single detection(Plt;0.05); With increasing of clinical stages, the level of serum CA125 is increasing gradually. Conclusion The combined detection of serum CA125, CA19-9 and CA72-4 has the important values in diagnosis and differential diagnosis of ovarian tumors, and is worthy of clinical application; The serum CA125 has important guiding role in disease assessment of ovarian cancer. [Key wordsJOvarian cancer CA125 CA19-9 CA72-4 Combined detection Clinical stage 卵巢恶性肿瘤是女性生殖系统常见的恶性肿瘤之一，因其早期症状隐匿, 60%-70%患者就诊吋多是lll?IV期，而晚期病例又疗效不佳⑴。故虽其发病率较 宫颈癌和子宫内膜癌低，死亡率却高居女性生殖系统恶性肿瘤之首。可见，早期 诊断对卵巢癌的治疗及预后显得尤为重要。 癌抗原125 (CA125)是卵巢癌中发现最早的一种肿瘤标记物，尤其作 为上皮性卵巢癌的重要肿瘤指标，其在临床上已得到广泛应用，在卵巢恶性肿瘤 的诊断、疗效评价及疾病监测等各个方面发挥着重要作用[2、3]o尽管其临床价 值已得到充分肯定，但仍有部分早期卵巢癌患者血清中不表达或很少表达 CA125[4],因此，检测其他相关肿瘤标记物，或与CA125联合检测已成为目前研 究热点，这也将进一步提高卵巢癌的筛查敏感性和特异性[5、6]o本文冋顾性分 析我院妇科2008年1月至2012年12月收治的63例卵巢癌患者的血清CA125、 CA19-9 CA72-4水平，同吋随机选取2012年1月至2012年12月收