血清IgA、C3及IgAC3在IgA肾病病理分级评估中的意义.docVIP

血清IgA、C3及IgA C3在IgA肾病病理分级评估中的意义 许慧丽何永成陈洪滔李彤 (深圳市第二人民医院肾内科 广东深圳518035) 【摘要】目的 比较IgA肾病患者不同病理分级的血清IgA、C3及lgA/C3水 ￥;探讨血清lgA、C3及lgA/C3水平在IgA肾病病理分级评估中的意义。方法 选 择我院320例经肾穿刺活检病理检查确诊为原发性IgA肾病患者，用散射比浊法 检测患者血清lgA.C3水平及按Lee氏分级标准评估IgA肾病病理分级。结果Lee 分级为I、II级与Lee分级为III、IV、V级患者IgA水平分别为 【(2.75plusmn;1.10)vs (2.85plusmn;1.26) g/L, (P 0.05)】；血清 C3 水平分别为 [(1.18plusmn;0.33) vs (1.04plusmn;0.29) g/L, (P 0.05)1 血清 lgA/C3 率分 别为【(2.71 plusmn;1.19) vs (3.24plusmn;1.69) g/Lz (P 0.05)1 结论 IgA/ C3 比值在评估IgA肾病病理分级有重要参考意义。 【关键词】血清IgA血清C3 血清lgA/C3比值 病理分级IgA肾病 【中图分类号]R969 【文献标识码】 A 【文章编号】2095-1752 (2014) 15-0143-02 The Relationship between the Serum IgA, C3 Levels, IgA/ C3 Ratio and Pathologicalgrading of IgA Nephropathy [abstract]Objective Observe the correlation between the serum lgA,C3 levels, IgA/ C3 ratio and Leersquo;s gradi ng system,explore the relati on ship betwee n the serum IgA, C3 Levels,IgA/ C3 Ratio and Pathological grading of IgA Nephropathy.Methods 320 patients with primary IgA nephropathy were diagnosised by renal biopsy in the second people hospital of ShenZhen,the levels of serum lgA,C3 were detected with turbidimetric method and the Pathological grading was evaluated according to the standard of Lee grading.Result The serum IgA levels of patients with Leersquo;s I and II grade was not higher than the patients with Leersquo;s III,IV, V grade【(2.75plusmn;1.10 VS 2.85plusmn;1.26) g/L,P 0.05] ;but the serum C3 levels of patients with Leersquo;s I and II grade was lower than the patients with Leersquo;s III,IV, V grade [(1.18plusmn;0.33 VS 1.04plusmn;0.29) ,P 0.05] ;and so was IgA/ C3 ratio in two groups [(2.71 plusmn;1.19VS3.24plusmn;1.69),P 0.05] .Conclusion The high of serum IgA/ C3 ratio appeared to be closely related with severity of pathology in patients with IgA nephropathy. 【Key words] Serum IgA Serum C3 Serum IgA/ C3 ratio Pathological grading IgA nephropathy IgA肾病(IgA nephropathy, IgAN)好发于青年患者,是我国常见肾脏病, 约占原发性肾小球疾病的40-47 % [1,2],是一种慢性进展性肾脏病，有研究报道 约20-25%在经过20-25年后缓慢发展至终末期