血清TGFβl水平和冠心病临床关系研究.docVIP

血清TGF- B I水平和冠心病临床关系研究 朱斌1柳茵2 (1四川攀枝花市第二人民医院心内科617068;2青海大学附属医院心内科 810001) 【中图分类号】R466.ll【文献标识码】A【文章编号】2095-1752 ( 2011) 22-0394-03 【摘要】目的探讨冠心病(CHD)不同临床类型患者外周血清中转化牛长因子 beta;l (TGF-beta;l)水平并结合选择性冠状动脉造影术结果的分析，探讨它 与冠状动脉粥样斑块程度和稳定性的关系，以期对TGF-beta;l在CHD发病机理 中的作用进行研究。方法选择我科住院的CHD患者72例，按临床症状分为亚 组急性冠脉综合征(ACS)44例，稳定型心绞痛(SAP) 28例。并经冠脉造影(CAG) 证实。对照组15例，并常规行冠脉造影排除冠心病。采用ELISA法测定血清 TGF?beta;l的水平。根据CAG术结果将CHD组分为三个亚组:单支病变、双支 病变和三支病变，左主干病变归为双支病变亚组。血管狭窄的部位由目测确定， 以狭窄ge;50%计病变冠脉支数。应用SYNTAX评分标准(运用从SYNTAX官方网 站所下载的SYNTAX评分计算)。结果CHD患者血清TGF-beta;l水平均显著低 于对照组，分别为 21012.3plusmn;13704.1 pg/mk52120.6plusmn;27424.0 pg/mlo (Plt;0.05)o ACS患者血清TGF-beta;l水平均显著低于SAP组, 29695.0plusmn;20561.3 pg/ml,21012.3plusmn;13704.1 pg/ml,差异有显著性 (Plt;0.05)oCHD患者血清TGF-beta;l与冠脉病变积分、病变冠脉支数呈负相关， 随着血清TGF-beta;l浓度相应降低，冠脉病变积分、病变冠脉支数值相应增加， 差异有显著性。结论 木临床试验结果倾向于血清TGF-beta;l在CHD患者中以 保护性作用为主。血清TGF-beta;l利于稳定冠心病患者的症状，减少ACS的发 牛；血清TGF-beta;l水平与慢性冠状动脉粥样硬化斑块的形成密切相关。 【关键词】TGF-beta;l冠心病 急性冠脉综合征 不稳定型心绞痛 The Clinical Research of TGF-beta;l in Patients with Coronary Heart Disease Zhubin 1, Liuyin2.1.Panzhihua NO.2 Peoplersquo;s Hospital,Sichan Province, Panzhihua (617068) ,China.2.Depart of Cardiology ,the Affiliated Hospital of Qinghai University.Qinghai(810001), China. 【Abstract] Objects Detected TGF-beta;l in the serum level of cor on ary heart disease, and an alysis correlati on of its re leva nee, explore it with cor on ary artery atherosclerosis plaques degree and stability of the relationship, in order to study TGF beta-1 in the role of CHD pathoge nesis. Methods 1. Study gruop in eluded cor on ary heart disease and control subjects.Experiment gruop were divided into 2 groups : stable angina pectoris(SAP) group and acute cor on ary syn drome(ACS) group.72 cases with CHD were collected from the Department of Cardiology, Panzhihua NO.2 Peoplersquo;s Hospital, and con firmed by cor on ary an giography (at least 1 vessel stenosis ge; 50%). The serum TGF-beta;l was measured by Enzyme-linked immunosorbe nt assay (ELISA) method.We got t