药学毕业头孢他啶连续与间断静脉给药治疗兔铜绿假单胞菌感染肺炎的比较研究.docVIP

XX大学 毕业论文 头抱他喘连续与间断静脉给药治疗兔铜绿假单胞菌感染肺炎的比较研究 姓 名： 2014年6月25日 头抱他唏连续与间断静脉给药治疗兔铜绿假单胞菌感染肺炎的比较研究 作者：胡秀娟王琪佟淑平王慧玲王莺燕王涛王伟 王岩岩 【摘要】 目的比较头抱他噪连续与间断静脉给药治疗兔铜绿假单胞菌感染 性肺炎的药动/药效学特点、组织渗透性及疗效。方法 采取连续与间断两种方式 以高、中、低三种剂量的头泡他噪治疗铜绿假单胞菌感染的新西兰白兔。绘制血 及肺泡间质液中头抱他碇的药 时曲线，计算TMIC、T4MIC、AUC、IQ等药 效学参数和肺组织渗透率，对比观察各组用药后疗效。结果连续组的TMIC、 T4MIC值明显高于间断组；间断组的IQ高于连续组；两者的AUC和组织渗透 率无明显差异；除间断给药低剂量组外，各组体温恢复情况无明显差异；治疗后 连续组肺组织病理改善较间断组改善明显。结论与间断给药相比，连续静脉滴 注的给药方式可得到更为稳定的血及肺组织中药物浓度，疗效更佳。 【关键词】 头抱他唳；铜绿假单胞菌；肺炎；连续给药；间断给药 ABSTRACT Objectives To evaluate the pharmacokinetic/pharmacodynamic characteristic, the penetration rates into lung tissues and the curative effects of ceftazidime administered in continuous versus intermittent infusion in a rabbit Pseudomonas aeruginosa pneumonia model. Methods Ceftazidime was given to rabbits infected by Pseudomonas aeruginosa either as continuous infusion (CI) or as intermittent administration (IA) with the same daily dose of 50 mg/(kg d), 25 mg/(kg d) or 15mg/(kg d) respectively. The concentrations of ceftazidime in both blood and epithelial lining fluid (ELF) were determined and the pharmacokinetic analysis was carried out for both regiments. The parameters including the time above the MIC, 4MIC (TMIC, T4MIC), the area under the concenrtration time curve (AUC) and inhibitory quotient (IQ) were compared. The penetration rates of ceftazidime into lung tissus were compared as well. Curative effect were evalua ted by observing the symptoms and physical signs in the course of the treatments, and the lung pathological characters were evaluated at the end of the course. Result Significantly higher TMIC, T4MIC wereobtained for the continuous versus intermittent administration. The IQs were higher for intennittent administration. No statistically significant different AUCs and penetration rates were found between the two regiments, and the same result among the six sub groups in the two regiments for the symptom and physical sign of the rabbits except the IA of 15mg/(kg d). The pathologic e