阻塞性睡眠呼吸暂停综合征患者体内氧化应激状态和抗氧化酶的变化及其临床意义.docVIP

阻塞性睡眠呼吸暂停综合征患者体内氧化应激状态和抗氧化酶的变化及其临床意义 张连勇 张骞云 吴坎金 李晓娟 于金香 宫艳格 (沧州市屮心医院河北沧州061001) 【摘要】冃的：研究探讨分析阻塞性睡眠呼吸暂停综合征患者体内的氧化 应激状态和抗氧化酶的变化及其临床意义。方法：选择2014年1月至2015年5 月收治的110例患者为研究对象，其中阻塞性睡眠呼吸暂停综合征患者55例作 为试验组，同期体检健康者55名作为对照组，均进行睡眠监测，采集全部研究 对象当口睡前及次口晨起静脉血和检测其屮的丙二醛及谷胱甘肽，过氧化氢酶及 谷胱甘肽过氧化物酶的含量。结果：在血清屮丙二醛水平方面，试验组远高于对 照组，但其睡前水平低于晨起；在血清屮谷胱甘肽水平方面，试验组显著低于对 照组，但其睡前水平高于晨起。在血清中过氧化氢酶含量方面，对照组中酶的活 性较试验组高；在血清屮谷胱甘肽过氧化物酶方面，对照组也较实验组高。以上 差异两组研究对彖均具有明显统计学意义。结论：阻塞性睡眠呼吸暂停综合征患 者的体内的氧化应激状态持续存在，其严重程度与患者病情的轻重有着极大的关 系，抗氧化酶减少，以致抗氧化水平减低，机体免疫力下降。 【关键词】阻塞性睡眠呼吸暂停综合征；氧化应激；抗氧化酶；临床意义 【屮图分类号1R563.8 【文献标识码]B 【文章编号11003-5028(2015 ) 8-0483-02 Patient with obstructive sleep apnea syndrome oxidative stress state and the change of antioxidant enzyme and its clinical significanee 【Abstract] Objective: To analyze patients with obstructive sleep apnea syndrome in the oxidative stress state and the change of antioxidant enzyme and its clinical significanee. Methods: 110 patients were treated as the research object 、 which were admitted between January 2014 and May 2014, obstructive sleep apnea syndrome in 55 patients as experimental group , and selected 55 medical healthy subjects as control group. Monitored them sleep and collected all the research object venous blood on the same day before sleeping and the next morning, and detected the content of MDA, GSH, catalase and glutathione peroxidase. Results: The MDA level in serum, experimental group was much higher than the control group, but the before sleeping level is lower than the morning level; the GSH level in serum, experimental group was much lower than the control group, but the before sleeping level is higher than the morning level. The catalase level in serum, control group was much higher than the experimental group, and the glutathione peroxidase level in serum, control group was much higher than the experimental group too. The above differences between the two groups had significant statistical significanee. Conclusion: Patients with obstructive sleep apnea syndrom