赣南地区糖化血红蛋白与2型糖尿病患者慢性并发症的相关性研究.docVIP

赣南地区糖化血红蛋白与2型糖尿病患者慢性并发症 的相关性研究 摘要：目的调研赣南地区2型糖尿病患者（T2DM）糖化血红蛋口 （HbAlc）的水平与其慢性并发症的关系。方法 选取我院2014年1月? 2016年1月内分泌科就诊的500例2型糖尿病患者，根据HbAlc水平分为 三个组：A组W7.0%、B组7%HbAlc〈10%和C组$10%,测定空腹血糖、 英他生化指标及糖尿病相关并发症的筛查。结果 三组间患者的血压、TC 和IIDL-C无显著性差异（P0. 05）o FBG、TG、和LDL-C水平比较差异显著 性差异（P〈0?05）,与HbAlc呈正相关；随着HbAlc水平上升，糖尿病视 网膜病变（DR）、糖尿病肾病和冠心病、脂肪肝的发病率升高（P〈0.05）。 糖尿病周围神经病变、糖尿病足（DF）和脑梗死的发病率组间差异无统计 学意义。结论 糖尿病患者的慢性并发症的发生随着HbAlc的升高而增加, 积极严格控制2型糖尿病患者的HbAlc冇利于防治糖尿病并发症的发生于 发展。 关键词：糖化血红蛋白；2型糖尿病；慢性并发症 The Correlation Study of Glycosylated Hemoglobin and Chronic Complications in Type 2 Diabetes of Garman Area ZHONG Shu-mei, YIN Ying, ZHANG Si-qing, ZENG Xian-zhong, XI Yan-hua, LI Xiao-yan (Department of Endoerinology and Metabolism, Ganzhou Peoples Hospital, Ganzhou 341000, Jiangxi, China) Abstract： Objective To study the correlation of glycosylated hemoglobin and chronic complicationsin type 2 diabetes of Gaimanarea? Methods 500 cases of type2 diabetes patients in our department of Endocrinology from Janurary2014 to Janurary2016. According to the HbAlc they were divided intoA group^7. 0%, B group 7%HbAlc 10% and Cgroup 三 10%, FBG , biochemical indicators weremeasured and diabetic complications were screened in all subjects .Results There was no significant difference in blood pressure, TC and HDL-C among three groups (P0. 05)?There were statistically significant differences inFBG, TGandLDL-C (P0.05), andpositively correlatedwith the HbAlc.The inci denee of diabetic retinopathy ( DR ), coronary heart disease ( CHD ) , diabetic n ephropathy (DN) and fatty liver in creased markedly along with the elevation of HbAlc levels (P0.05)? There was no significant differc ncc in the in cidence of diabetic peripheral n europathy (DNP ), cerebral infarction and diabetic foot? Conelusion Chronic complications in diabetic patientsclosely related to glycosylated hemoglobin content , dwith elevated HbAlc increase , strict control of type 2 diabetes HbAlc in favor of prevention and treatment of diabetic complications occur