转化生长因子-在哮喘气道炎症与重塑中的作用.PDFVIP

Chinese Journal of Pathophysiology 2004 20( 8) : 1527- 1530 ∃ 1527 ∃ [ ] 1000- 4718( 2004) 08- 1527- 04 - 李明才 何韶衡 ( 515031) Role of transforming growth factor- in the airway inflammation and remodeling in asthma LI Ming- cai HE Shao- heng (A llergy and Inf lammation Research Institute, Shantou Univ ers ity M edical College, Shantou 515031, China) A Review Transforming growth factor- ( TGF- ) w as reported to be increased in asthma in some studies. Accumulation of TGF- in airway promotes smooth muscle cell mitogenesis and hyperplasia and in duces fibroblast and myofibroblast and smooth muscle proliferation as w ell as increase in protein synthesis in connective tissue( such as collagen deposition on the reticular basement membrane) . The autocrine indu ct ion of collagen expression by smooth muscle may contribute to the thickening of the ret icular basement membrane irre versible fibrosis and remodeling seen in the airways in some asthmatics. TGF- is considered to be a major fi brogenic cytokine. It can increase smooth muscle mass and lead to severe bronchial obstruction in an asthma at tack . [ ] ; ; ; [KEY WORDS] Asthma; Tran sforming growth factor beta; Inflamm ation ; Airw ay remodeling [ ] R5622+ 5 [ ] A ( asthma) TGF- 1TGF - 2TGF - ( airway hyperresponsiveness AHR) 3 19q31q4114q24 ( T 7 ) TGF- 1 mRNA 24kb TGF- 390 TGF - ( latency associated pep tide LAP) 2 - ( Trans LAP TGF - 25 kD forming growth factor- TGF- ) 125 kD ( 112 ) TGF- TGF- TGF- TGF - 1 1 GF- TGF- TGF -