老年男性血清抵抗素水平与心血管相关疾病的关系一项横断面调查研究老年医学专业论文.docxVIP

军医进修学院博士学位论文 军医进修学院博士学位论文 PAGE PAGE 2 素；5、CHF 组患者血清抵抗素水平显著高于相应对照组，在二元 logistic 回归 分析中，在分别校正年龄和 CRP 后，抵抗素均不是 CHF 的危险因素，表明年 龄和 CRP 在 CHF 发生和发展中均是抵抗素以外的重要因素；6、AF 组患者血 清抵抗素水平显著高于相应对照组，在二元 logistic 回归分析中，在校正 CRP 后，抵抗素仍是 AF 的危险因素，而在校正年龄后，二者的这种关系消失，表 明年龄在 AF 发生和发展中是抵抗素以外的另一重要因素；7、CKD 组患者血清 抵抗素水平均高于相应对照组，在 CKD 组和非 CKD 组，Cystatin-C 均与抵抗 素水平独立相关，在二元 logistic 回归分析中，在校正年龄、CRP 以及病史后， 抵抗素是 CKD 的独立危险因素。 结论：1、血清 Cystatin-C、CRP、NT-pro-BNP 和 HDL-C 水平与血清抵抗素水 平独立相关；2、抵抗素和 CRP 与 MtS、CHD、PAOD 和 CHF 疾病相关，推测 抵抗素可能通过促进炎症反应而参与 MtS、CHD、PAOD 和 CHF 的发生发展； 3、抵抗素与 AF 疾病相关，但 CRP 与上述二者之间的关系无关，推测抵抗素是 否通过炎症以外的途径参与了 AF 的发生发展？尚需进一步研究；4、抵抗素是 CKD 的独立危险因素；5、由于本研究为横断面调查，因此，仅能够得出初步 的结论，关于抵抗素与上述疾病之间的因果关系，尚有待于更大规模的随机对 照研究进行证实。 关键词：老年；男性；抵抗素；心血管疾病 Title: The relationship between the serum resistin levels and cardiovascular diseases in elderly men: a cross-sectional study Abstract Objectives: to determine the relationship between the serum resistin levels and cardiovascular diseases in elderly men. Material and methods: 843 men (aged 60 and older) were enrolled. The body height, body weight and blood pressure (SBP and DBP) were measured. The serum levels of resistin, Cystatin-C, CRP, NT-pro-BNP, lipid profiles (TC, TG, LDL-C and HDL-C), glucose, Cr were determined and GFR was calculated. The correlation analyses were performed with these continuous variables. The multiple linear regressions were performed with the serum levels as independent variable. Then, the whole corhort was divided into groups according to cardiovascular diseases (MtS, hypertension, DM, obesity, CHD, PAOD, CHF, CKD and AF). The serum resistin levels were compared between the groups with these disease and the control groups without these diseases. The binary logistic regressions were preformed with these diseases as independent variables. Results: 1. In the whole corhort, the serum resistin levels were negatively correlated with eGFR (p0.001), DBP (p0.05), TC (p0.001), LDL-C (p0.001), HDL-C (p0.001); were positively correlated with age (