凉开法的作用机理及临床应用-中医临床基础专业论文.docxVIP

凉开法的作用机理及临床应用研究 凉开法的作用机理及临床应用研究 ABSTRACT This article includes researches in theory and animal experiment In the theoretical research，directing by the science of epidemic febrile disease，combining with Western Medicine and resuks of animal experiment as well clinical case studies，the pathogenic factors of warm poison，blood stasis and phlegm stagnancy in sympterm of method of cool resuscitation are expounded systematically and completely In febrile disease treatment，the method of cooling pericardium，clear phlegm and removing blood stasis，resuscitation by opening orifices and etc The mechanism of these functions are also analysed；in addition，the indications special for this method，the distinctive composing prescription and the coordination of relate treatment etc are put forward In experiment research，the animal model of hyperthermia made，and the therapeutic effect of OingKaiLing(QKL)ale studied，which is the reformed Dpical prescription that belong to the method of cool resuscitaion，the reaults showed this method has obvious funotion of restrian and decrease the temperature in rat during hyperthermia It’s mechanism may be produced by affecting nerves messengers of monoamines in hypothalamus KEY WORDS Cool Resuscitaion／Chinese Traditional Medicinal Therapy mechanism clinical application 查塞主垦堕奎兰!!!!堡璧主兰垒堡壅————理论部分 查塞主垦堕奎兰!!!!堡璧主兰垒堡壅———— 理论部分 前言 凉开法是集清心泄热，涤痰化瘀，开闭通窍等为一体的综合性治疗方法。 本法具有清心泄热，涤痰化瘀，开闭通窍等作用[卜3]，是治疗温病过程中 邪在心包而致神志病变的～种重要方法。由于在邪闭心包的病理演变中存在着 温邪由浅入深、耗伤阴血、成痰结瘀、阻闭包络的过程，在这一病变的过程中， 热毒内闭是引起包络受邪的根本原因，由此而产生的痰浊、瘀阻与热毒相结合 阻于包络，成为热闭心包证的主要病理状态，而痰蒙、瘀阻作为病变过程中的 病理产物，又可作为疾病中的致病因素，从而在热闭心包证中出现热、痰、瘀、 闭相结合的错综复杂状态。在疾病的早期，热毒入侵的表现铰为突出，病至中 后期。痰蒙、瘀阻窍闭等病理表现较为严重[4]。 上述病理变化也往往会出现在某些内伤杂病中。在杂病热闭证的病变过程 中，痰浊、瘀阻、热毒可同时并存，也可以以某一病理状态为主，以中风为例， 病人往往表现为高热、意识障碍，大脑出血或缺血等一系列痰热、瘀热或痰瘀 相互博结阻于心包的证候，从而形成热、痰、瘀闭阻包络的病理状态[5]。 在病变的初期常因热盛痰瘀闭阻包络而表现为高热、神昏、半身不遂等临床表 明，病至后期，则因痰浊瘀血滞留脑络、经脉，热瘀或痰瘀互结阻于络脉而有 失语、肢体瘫痪等后遗症L6]。因此，某些内科杂病也可出现与邪入心包相 类似的病理变化。因而针对这一病理变化，凉开法能否借鉴用于内科杂病的某 些