探讨丙种球蛋白治疗儿童不敏感川崎病的临床研究.docVIP

探讨丙种球蛋白治疗儿童不敏感川崎病的临床研究 郴州市第三人民医院湖南郴州423000 摘 要 目的探讨静脉注射丙种球蛋白IVIG对儿童不敏感川崎病的 临床研究。方法选取2014年1月至2016年1月木院儿科收治的川崎病住院患 儿60例，60例患对比分析两组之间的白细胞(WBC),中性粒细胞(N),外周 血血红蛋白(Hb), C反应蛋白(CRP),白蛋白(ALB),乳酸脱氢酶(LDH),血 沉(ESR)等指标，以及对比伴随冠状动脉病变和不伴随冠状动脉病变的患者的 类似指标，对患者的IVIG耐药高危因素进行logistic回归分析。结果IVIG敏感组 ALB高于IVIG不敏感组(Plt;0.05),其他指标比较差异无统学意义(Pgt;0.05)o 伴随冠状动脉病变患者的热程与不伴随冠状动脉病变患者比较，差异有统计意义 (Pgt;0.05),釆用Logistic In]归对血浆ALB年龄与川崎病发生耐IVIG相关性进 行分析，经X 2检验表明，年龄和ALB是导致IVIG耐药的高危因素(Plt;0.05)o 结论IVIG不敏感患儿较敏感患儿更易发牛冠状动脉病变其中年龄ALB可能是患 儿IVIG耐药的高危因素复用IVIG及在抗凝基础上加用激素对IVIG不敏感川崎病 治疗有效。 关键词 丙种球蛋白；不敏感川崎病；临床研究 [Abstract] Objective clinical study of intravenous immunoglobulin IVIG in children is not sensitive to Kawasak「s disease.Methods January 2014 to 2016 January in our hospital of Kawasaki disease 60 cases of hospitalized children with, 60 cases suffering from comparative analysis between the two groups of white blood cell (WBC) and neutrophils (n), peripheral blood hemoglobin (HB), C-react:ive protein (CRP), albumin (ALB), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR) (ESR) and other indicators, and compared with coronary artery disease and not accompanied by similar in dex in patie nts with cor on ary artery disease, for patients of IVIG resista nee risk factors logistic regression an alysis.Results the ALB sensitive group was higher than IVIG in the IVIG group (Plt;0.05), and the other in dexes were not sign 讦 icant (Pgt;0.05) .Alo ng with the thermal history of cor on ary artery disease and is not accompa nied in patie nts with cor on ary artery disease compared with statistical significance (P gt; 0.05), using logistic regression to plasma albumi n (ALB) age and Kawasaki disease resista nt re leva nee IVIG were an alyzed and the x2 test showed that, age and ALB is lead to IVIg resista nt drug risk factors (P lt; 0.05) .Conclusion IVIG sensitive children more sensitive children more susceptible to cor on ary artery disease including age ALB may IVIG resista nee in patients with high risk fa