心衰儿血浆氨基末端B型利钠肽前体检测临床意义浅析.docVIP

心衰儿血浆氨基末端B型利钠肽前体检测临床意义浅析 祁晓慧 (安徽省儿童医院 安徽 合肥230000) 目的：探讨血浆氨基末端B型利钠肽前体(NT?proBNP)心衰判断指 标和改良Ross标准⑴青岛标准的符合率、相关性及在心源性与非心源性呼吸困 难诊断的鉴别意义。方法：将100例心衰患儿随机分为心衰组、无心衰组(以下 简称A组、B组)，每组各50例，另选取保健体检健康小儿50例(以下简称C 组)，对照血浆NTproBNP水平，测定A、B组治疗前后的NT-proBNP水平，计 算NT-proBNP心衰判断指标与改良Ross标准及青岛标准的符合率，确定血浆 NT-proBNP在心源性与非心源性呼吸困难诊断的鉴别意义，拟定心衰联合诊断标 准，确定血浆NT-proBNP在心源性与非心源性呼吸困难诊断的鉴别意义，并进行 统计学分析。结果：三组比较差异显著，具有统计学意义。结论：NT-proBNP可 以作为心衰诊断的敏感牛物学指标物。 关键词 心衰患儿；判断指标；呼吸困难诊断 R562 A 2095-1752 (2016) 18-0064-03 Heart failure and plasma amino-terminal b-type natriuretic peptide precursor detection of clinical significanee Qi Xiaohui. Childrens Hospital in Anhui Province” Anhui Province, Hefei 230000, China [Abstract Objective Discusses plasma amino-terminal b-type natriuretic peptide precursor (NT - proBNP) heart failure judgment index and improved the accuracy of Ross Qin gdao stan dard, re leva nee and heart source sex ide ntificati on and diagnosis of cardiac dyspnea. Methods 100 cases of children with heart failure were randomly divided into heart failure group (group A) and the heart failure group (group B), each 50 cases in each group? Other selected 50 cases of pediatric care medical health (group C), control the plasma NT - proBNP levels, the determination of A and B group before and after treatment of the NT - proBNP level, computing the NT - proBNP heart failure judgment index and improved Ross standard and the coincidenee rate of the Qingdao standard etc., and statistical analysis. Results Three groups is more sign ifica nt d iff ere nee, statistically sign 讦 icant. Conclusions NT - proBNP can be a sen sitive biological in dex of heart failure diag no sis. Key words］ Children with heart failure; Judge index; Breathing difficulties in diagnosis 小儿心衰（急性心衰和慢性心衰）是儿科最常见的危重病症，引发的因素分 为心源性和非心源性，最常见的是肺炎和先天性心脏病，前者会导致急性心衰， 后者则常导致慢性心衰。目前的儿科心衰诊断标准大多采用的是改良Ross标准、 青岛标准和纽约大学小儿心衰指数（NYU PHFI）评分标准［2］。这几种标准都有着各 自的特点、优长。相关研究表明，氨基末端B型利钠肽前体（NT?proBNP）可作为 心衰诊断的敏感生物学指标物。本人在上述国内外公认的心衰诊断标准的基础上, 通过对50例心衰、50例非心源性