心脏死亡儿童供体单肾移植的疗效分析.docVIP

心脏死亡儿童供体单肾移植的疗效分析 1.中南大学湘雅三医院湖南长沙410013 摘 要 目的评估供体年龄在2岁以上的心脏死亡儿童供体单肾移 植(SPKT)的临床疗效，并探讨其应用价值。方法回顾性分析我中心自2010 年到2014年开展的26例SPKT和109例心脏死亡标准供体肾移植(SCDKT)o对 比两种肾移植术后供受体的基木资料及术后早期并发症的发牛率，比较、分析两 种肾移植术后1年内移植肾的长径、功能、移植肾存活率和受者存活率之间的差 异，评估心脏死亡儿童供体单肾移植的临床疗效。结果SPKT组与SCDKT组术 后早期并发症的发牛率无明显差异(Pgt;0.05)； SPKT术后移植肾的成长能力明 显优于SCDKT组；两组术后各时间点的肾小球滤过率(eGFR)、移植肾存活率及 人存活率之间均无统计学差异(Pgt；0.05)o结论当心脏死亡儿童供体的年龄 大于2岁时，SPKT不仅术后移植肾有良好的成长能力，其临床疗效也可与SCDKT 相媲美，是尿毒症患者的理想选择，其合理应用有助于扩大器官来源。 关键词 心脏死亡捐献；儿童供体；肾移植；体表面积 The analysis of outcomes on single pediatric kidney transplantation from cardiac death deceased donors Zhi-tanPENGl, Qi-fa YE1, Ke CHENG1, Yu-jun ZHAO1, Lian LIU1, Qiang WANG1 (l.The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013；) Abstractobjective To analyze the outcomes and discuss the application of single pediatric kidney transplantation (SPKT) from cardiac death deceased donors (2-18yr). Methods We retrospectively analyzed 26 cases of SPKT from cardiac death deceased donors and 109 cases of standard-criteria donor kidney transplantation (SCDKT) that were performed in our center from 2010 through 2O14.We analyzed the outcomes of SPKT by con ducting comparis on betwee n SPKT and SCDKT in demographics of patients, early postoperative complications, the length and function of grafts, and graft and patient survival. Results There was no difference between SPKT and SCDKT in postoperative complications (Pgt;0.05) .The length of graft within half a year in SPKT was much shorter than that of SCDKT (Plt;0.05), however, the length of each group became almost equivalent as time went on.No sign 讦 icant d iff ere nee was show n betwee n each group in eGFR, graft and patient survival post kidney transplantation. Conclusion Once the age of pediatric donors is above 2 yrs, the SPKT can obtain comparable outcomes to SCDKT and better capacity of graft growth, which is an ideal choice for uremia patients.Appropriate use of pediatric donors can significantly expand the donor pool.