炙甘草汤加减联合西药治疗慢性心力衰竭的临床研究.docVIP

炙甘草汤加减联合西药治疗慢性心力衰 竭的临床研究 毛美娇胡道卿刘宇邓兵 上海中医药大学附属龙华医院南京明基医院 摘要： ［目的］探讨炙甘草汤加减联合西药治疗慢性心力衰竭的临床疗效。［方法］将60 例辨证为气阴两亏型慢性心力衰竭患者随机分入中西药联合治疗组和单纯西药 治疗组，分别予以口服中药炙廿草汤加减联合西药基础治疗及单纯口服西药基 础治疗1个月。观察并记录用药治疗前和用药1个月后的安全性指标、疗效指标 （中医证候积分、纽约心脏协会心功能分级、Lee积分、明尼苏达生活质量量表、 六分钟步行距离）及理化指标B型尿钠肽（BNP）的变化，并进行组间比较统计 学分析。［结果］中西药联合治疗组较单纯西药治疗组，可明显减轻患者中医临床 证候表现，各项心功能评分指标改善程度更明显，且差异有统计学意义 （P0. 05），治疗后患者安全性指标未见明显异常。［结论］炙甘草汤加减联合西 药治疗气阴两亏型慢性心力衰竭安全有效，可减轻患者临床症状、改善患者的生 活质量与心功能。 关键词： 慢性心力衰竭;气阴两亏型;炙甘草汤; 作者简介：毛美娇（1985-），女，主治医师，主要研究方向为中西医结合防治 心血管疾病。 作者简介:刘宇，E-mail:liu yuu@sina. com0 收稿日期:2017-08-06 基金：上海市中西I矢结合学会科研课题项目（SZXYK-201501） A clinical study of Zhigancao decoction with basic treatment on patient with chronic heart failure MAO Mei-jiao HU Dao-qing LIU Yu DENG Bing Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Nanjing Benq Medical Center; Abstract： [Objective] Research by using the method of randomized prospective. [Methods] Sixty patients with both qi and yin deficiency syndrome of chronic heart failure were divided into two groups: the treatment group and the control group. Only control group were given basic treatment to control heart fai lure symptoms, treatment group with basic treatment have takcn orally Zhiganceio decoction. Observed emd recorded the safety index， the efficacy index traditional Chinese medicine symptom scores, Lee points, Minnesota quality of life scale, six-minute walking distance) and physicochemical indicators (BNP) before the treatment and one month later. [ResuIts] Western medicine with Zhigancao decoction in patients with chronic heart failure syndromes improvcment was better than western medicine. [Conclusion] Zhigancao decoction can significantly improve qi and yin deficiency symptoms of CHF patients and improve quality of life. Keyword： chronic heart failure; qi and yin deficiency type; Zhigancao decoction; Received： 2017-08-06 炙甘草汤出自东汉张仲景《伤寒论》太阳篇，原文第177条：“伤寒，脉结代，心 动悸，炙廿草汤主之。”在《金慣要略?虚劳》、《金质要略?肺痿》作为附方 出现;为益气养阴的要方，过去多用于气阴两亏型心律失常和各种虚劳的治疗 UL近年来刘宇主