合理选择核苷酸类似物降低抗乙肝病毒有效治疗失败风险.pptVIP

* 这里讨论慢性乙型肝炎的治疗，没有特别强调肝硬化，因此后面患者的诊断及指南的建议也没有包括肝硬化患者 * 强调只有通过HBV DNA持续抑制才能达到乙肝治疗的最终目标。 * * * * * * Speaker Notes Key Point: This slide has been seen already; sufficient to recap that viral load falls off in a biphasic manner much more quickly in the first 11 weeks of therapy with ETV vs ADV. ADV rate of onset and absolute potency limits this drug’s effectiveness. Background: In a study comparing ETV vs. ADV, ETV-treated nucleoside-na?ve HBeAg(+) patients were seen to have a significantly more rapid decline in viral load from as early as Day 10 through to Week 12. Simulated kinetics of viral