ELAVL1在前列腺癌中的表达及意义.docxVIP

ELAVL1在前列腺癌中的表达及意义 梁涛李作为田斌强李永辉傅强 【摘 要】 目的 探讨ELAVL1在前列腺癌(Pea)中的表达及意义。方 法 应用免疫组化SP法检测66例Pea、18例高分级前列腺上皮内瘤(HGPIN)、 30例前列腺增牛组织(BPH)及15例正常前列腺组织(NP)中ELAVL1的表达。结果 46例(69.70%) Pea中ELAVL1有中等或强的表达，18例HGPIN中ELAVL1都是 弱或中等的表达，30例BPH和15例NP没有或只有弱的表达。前列腺癌Gleason 评分(GS) 8J0组中ELAVL1表达明显高于GS7组和GS5-6组(Plt;0.05) ,GS7 组中ELAVL1表达明显高于GS5-6组(Plt;0.05) ,GS7中GS (4+3)组中和GS (3+4)组中ELAVL1表达没有明显区别(P=0.827)o结论 ELAVL1的表达可能 与Pea的发牛机制有关，其对诊断高分级前列腺上皮内瘤和判断前列腺癌的转移 和患者的预后有重要意义，ELAVL1可作为前列腺癌治疗的新靶点。 【关键词】ELAVL1； 前列腺癌；转移 Expression and significance of ELAVL1 in prostate neoplasm. LIANG Tao, LI Zuo-wei, TIAN Bin-qiang, LI Yong-hui, FU Qiang. (Department of Urology, Shanghai Jiao Tong University Affiliated Sixth Peoplersquo;s Hospital, ShangHai 200233， P.R.China) 【Abstract] Objective To study the expression and significanee of ELAVL1 in prostate cancer (Pea). Methods The expression of ELAVLl was assayed by means of immunohistochemical technique in 66 Pca 18 high grade prostatic intraepithelial neoplasia (HGPIN) 30 benign prostatic hyperplasia(BPH) and 15 normal prostate tissue(NP) specimens. Results ELAVLl expression was moderate or strong in 46(69.70%) Pea and all of 18 HGPIN were moderate or weakly while negative or weakly in BPH and NP. ELAVLl expression were higher in the Pea with Gleason score(GS)8-10 than those Pea with GS7 and GS5-6(Plt;0.05), ELAVLl expression of Pea with GS7 were higher than those Pea with GS5-6(Plt;0.05) ‘while no difference was found between GS7(4+3) and GS7(3+4) cancers(P=0.827). Conclusions The express!on of ELAVL1 may be involved in the pathogenesis of Pea, and ELAVL1 expression may be useful for the HGPIN diagnosis and the patientsrsquo; prog no Stic estimatati on. It may be the no vel target for Pea treatment. 【key word] ELAVL1； Pea； metastasis 前列腺癌是老年男性的常见肿瘤，其发病率呈增加趋势，在世界范围内前列 腺癌的发生率在男性所有恶性肿瘤中位居第二【1】。前列腺癌在我国自2008年 起已经成为泌尿系统中发病率最高的肿瘤【2】。局限性前列腺癌可以通过根治性 前列腺切除术和放射疗法治疗。对于晚期前列腺癌内分泌疗法依然是治疗的主要 方法。但是，晚期前列腺癌内分泌治疗后往往会转变到去势抵抗性前列腺癌 (CRPC) [3],这也是这部分病人死亡的主要原因。无疑，了解前列腺癌的病因 和发病机制将有助于我们的治疗。另