大剂量沐舒坦对急性呼吸窘迫综合征患者呼吸力学、细胞因子、氧合和抗氧化能力的影响.pdf

1仁中利披人学州济I廷学院 坝I‘学位论史 andhas and of withARDS anti—oxidant anti．．ilaflammatoryactivitypatients on and mechanicsofARDS beneficialeffectsoxygenationrespiratory patients． 42 with wereenrolledinthe were Methods ARDS study．They patients divided into2 in AweretreatedwithO．9％ randomly group groups．Patients in Breceiveddose NaCl(500m1)alone，and ambroxol(20 patientsgroup high consecutiveblood nag‘kg“)+O．9％NaCl(500m1)for7days．Thesamples weretakenforblood SOD and measurements gas，serHm activitycytokines before after thefirst and7 thefirstinfusion infusion，5 days days respectively． Serum and 13，IL一6，IL-8，IL一10，11师一a cytokines(IL一1 GS-csF)were detenninedELISA．The of by Parameters and oxygenationrespiratory mechanicswererecorded．Outcomeof inboth patients groupsincluding various functionindiceswere puhnonary analyzed． ResultsThe and ofthe in B Pa02，Sa02Pa02／Fi02 patients groupimproved