巨噬细胞移动抑制因子基因启动子区CATT微卫星多态性与脓毒症发生发展的相关性.pdfVIP

CATTnmicrosatelliteinthe Afunctional Of prOmoter macrophage f．actorin migra廿oninhibitorysepsis of RullR11nShaw DepamlentAnaesthesiolo移，Sir Hospital， zhejiallguniVers蚵 student：Hu Postgradute Don鲥un Tutor： FangⅪangming Abstract aⅡd BackgroundObjectiVe factor is a inllibitou (M巧) Macrophagemigration potent cytokine．An roleforⅣⅢ7wimint11e pro—inn锄matory important cascadeistoactinconcertwitll cytokille endogenous91ucoc硎coids tocon仃01the and oftlle set—pointmagnitude MIF a roleinthe of eleVated playspivatol pathogenesiss印sis．An ofMIFinthecirculationhasbeendocumentedtobe eXpression andfataloutcome associatedwi血t11eseV甜ty of high s印sis microsatelliteat AnovelCATr_te缸anucleotide of repeatposi位on一794 t11ehuman hasbeen a虢cts血e MⅢgene discoVered．It如nctionally t11eMⅡF This gene activi够of promoterusing reporterassays． offollr which diverseCArrr