Graves病患者血清Ghrelin水平与甲状腺功能状态的关系.docVIP

Graves,病患者血清Ghrelin水平与甲状腺功能状态的关系 杨士军1；崔兆辉2；陆卫平2 南京医科大学附属淮安第一医院 1核医学科 2内分泌科（江苏淮安223300） 摘要：目的 为探讨Graves,病患者血清生长激素释放肽（Ghrelin）水平与甲状腺激素之间的关系。方法 采用酶联免疫法（ELSIA）测定正常成人(33例)和初发Graves,病患者（67例）治疗前后血浆Ghrelin水平，分析血浆Ghrelin与FT3、FT4、S-TSH的关系。结果 Graves,病患者血浆Ghrelin水平较对照组明显降低，分别为(0.99±0.18ug/ml 、1.27±0.16ug／ml， p0.05)。经他巴唑治疗3个月后血浆Ghrelin水平与正常对照组比较无明显差异（分别为1.19±0.27 ug/ml 、 1.27±0.16 ug／ml, p0.05）。相关性分析表明血浆Ghrelin水平与血清FT3、FT4浓度呈明显负相关(r=-0.36 和 r=-0.41 p值都0.05)，而与血清s-TSH呈明显正相关(r=0.27 ，p0.05)。结论 Graves，的病程中伴随有血清Ghrelin的改变，甲状腺激素可能对中枢或外周Ghrelin的产生和分泌具有直接的调控作用。 关键词：生长激素释放肽；Graves,病；甲状腺激素 中图法分类号：R33；R581.1 The Relationship Between Serum Ghrelin And Thyroid Functional Status In Patients With Graves’ Disease NO1 Hospital of Huaian affliated with Nanjing Medical University Yang Shi-Jun;Cui Zhao-Hui;Lu Wei-Ping Abstract：Objective To discuss plasma ghrelin levels in the patients with Graves and their relation to thyroid hormones．Methods Plasma ghrelin levels were assayed by ELISA in 33 normal subjects and 67 Graves, patients before and after medical treatment．The relationship between plasma ghrelin levels and thyroid hormones was also analyzed．Results Plasma ghrelin levels were significantly lower in the Graves, patients than the controls(0.99±0.18ug/ml vs 1.27±0.16ug／ml p0.05)．After Methimazole treatment for 3 month,plasma ghrelin levels were similar to the controls(1.19±0.27 ug/ml vs 1.27±0.16 ug／ml, p0.05)．Plasma ghrelin levels were correlated negatively with FT3 and FT4(r=-0.36 and r=-0.41 both p0.05)，and correlated positively with s-TSH (r=0.27 p0.05). Conclusion The thyroid hormone may have direct regulation Oil the production and secretion of central or periphery ghrelin． Key word: Ghrelin, Graves’ Disease, thyroid hormone 1 对象与方法 1,1 对象 Graves,病组,为我院门诊初诊的Graves,病患者,共67例(男性18例，女性49例)。诊断标准：根据临床表现、体格检查和血清甲状腺激素结果(s-TSH0.27 mIU/L、FT37.1pmol／L、FT422 pmol／L)。分别于确诊后、给予甲巯咪唑30mg/d治疗3月后空腹采血测定s-TSH、FT3、FT4、Ghrelin。患者受试前未服用其它药物，受试期间无感染及其它疾病。 正常对照组，共33例（男性9例，女性24例）。为来我院体检人员，选择体格检查、血清检查、B超、