干细胞向胰岛样细胞诱导分化的研究进展-生命科学.PDF

18 1 Vol. 18, No. 1 2006 2 Chinese Bulletin of Life Sciences Feb., 2006 1004-0374(2006)01-0075-05 510632 1 2 Q813; R587.1A Research progress of differentiation of stem cells into islet-like cells LU Yan, ZHANG Yuan* (Insititute of Hematology, Jinan University, Guangzhou 510632, China) Abstract: The morbidity rate of diabetes mellitus is increasing at present, which is a serious disease damaging human being’s health. The transplantation of pancreatic islet cells has been used to treat the diabetes type 1 and 2. However, it is necessary to search new sources of insulin-secreting cells for cell therapy of diabetes mellitus due to lacking of sufficient donor cells. With the development of cell therapy and tissue engineering in recent years, the new way of new islet cells from stem cells has be found, which can provide new islets for curing of diabetes. The progress of differentiation from stem cells into islet-like cells, problems and prospect will be discussed in the review. Key words: stem cell; diabetes mellitus; cell therapy 1 1995 8% (diabetes mellitusDM) 2000 WHO Shapiro [1] 1.7 2025 (Edmonton)7 3 1 1 6 000 2 130 000 20 90 [2] 2005-07-18 2005-09-16 (2005) (1978 ) (1948 ) * 7 6 ing cell cluster, IPCC) 10%13% (embryonic stem cell, ESC)(adult ste