基于整合药理学策略的元胡止痛方研究进展.docVIP

基于整合药理学策略的元胡止痛方研究进展 　　[摘要]中药方剂是中医临床治疗的主要形式和手段，探索中药方剂的化学物质实体与机体生命活动的交互规律，是中药研究的关键科学问题之一。目前，中药研究存在整体与局部脱节、宏观与微观脱节、体内过程与活性评价脱节，整合药理学的提出，为解决中药研究“碎片化”问题提供了一条切实可行的途径。近年来，该课题组采用整合药理学策略，对元胡止痛方进行了系统研究，建立了“化学指纹-代谢指纹-网络靶标”和“肠吸收-活性评价-数据挖掘”2个研究模式，从计算、体外和体内多个层次建立了该方剂的化学成分与生物活性之间的交互规律，为该方剂的质量控制、药效物质基础及其药理作用机制提供了依据，该文对相关研究进展进行综述。 　　[关键词]元胡止痛方;整合药理学;体内过程;活性评价;关联规律 　　Research of Yuanhu Zhitong prescription based on 　　strategy of integrative pharmacology 　　MA Yan， ZHANG Ying-chun， TAO Ye， CHEN Xiao-meng， WANG Peng， XU Hai-yu*， YANG Hong-jun* 　　（Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences， Beijing 100700， China） 　　[Abstract]Chinese medicinal formulae （CMF） were usually used in the clinics of traditional Chinese medicines （TCM）， which were critical for modernization of Chinese medicine to shed light on the interaction between CMF and biological organisms. However， correlation between system and part， macroscopic actions and microcosmic mechanism， ADME process and pharmacologic actions were usually neglected. The put-forward of integrative pharmacology provided a feasible approach to solve the problem of the fragmentation of TCM. For the past years， we applied the strategy of integrative pharmacology to study Yuanhu Zhitong prescription（YZP） systematically， and established two modes， chemical fingerprints-metabolism fingerprints-network targets and intestinal absorption-activity evaluation-data mining， to establish the interaction rule between the chemical composition and biological activity from multiple levels， such as the calculation and in vitro/vivo， which provided proof for the quality control， pharmacodynamic material basis and pharmacological action of YZP. In this paper， we summarized the related progresses of the research of YZP. 　　[Key words]Yuanhu Zhitong prescription; integration pharmacology; ADME process; activity evaluation; association regularity 　　doi：10.4268/cjcm 　　中药方剂是中医临床治疗的主要形式和手段，探索中药方剂的化学物质实体与机体生命活动的交互规律，是揭示中