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thematic review
Thematic Review Series: Lysophospholipids and their Receptors
An update on the biology of sphingosine 1-phosphate
receptors
1
Victoria A. Blaho and Timothy Hla
Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical
College , New York, NY 10065
Abstract Sphingosine 1-phosphate (S1P) is a membrane- during development and ageing. S1P , S1P , and S1P are es-
1 2 3
derived lysophospholipid that acts primarily as an ex- sentially ubiquitously expressed, whereas expression of S1P4
tracellular signaling molecule. Signals initiated by S1P are and S1P5 are highly restricted to distinct cell types ( 4 ).
transduced by five G protein-coupled receptors, named Production of S1P can be initiated by external or inter-
S1P . Cellular and temporal expression of the S1P recep-
D
1–5 nal signals, which lead to activation of the biosynthetic
tors (S1PRs) determine their specifi c roles in various organ o
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