CA199在胰腺癌诊断中的意义及文献评价.docVIP

血清CA199在胰腺癌诊断中的价值及文献评价 秦雪1 邓燕1 陈健 1 廖湘成 1 劳小霞 1 胡春卉1 陈智平2* 李山1* 1广西医学大学第一附属医院临床医学实验部 广西南宁 530021 2广西医科大学公共卫生学院 广西南宁 530021 摘要：目的 运用循证医学的方法对血清癌胚抗原（CA）199诊断胰腺癌价值做文献评价。方法 参照诊断性试验的评价标准，对文献的设计方案、研究对象的选择、参考值的确立、诊断试验的评价指标等进行评价。结果 纳入的17篇文献中有16篇与金标准进行了比较，但未提及是否采用盲法；所提供的诊断性指标（敏感度、特异度、似然比等）不全面，对偏倚的控制没有描述，对采用同一种方法测定的研究文献，其所得结论不完全相同。 结论 提示目前尚无临床证据表明CA199可作为诊断胰腺癌的独立指标。 关键词：CA199抗原； 胰腺癌； 文献评价 中国分类号：R4 Evaluation of the Value of Serum CA 199 in Literature of Pancreatic Cancer Based on Evidence-based M QIN Xue1 DENG Yan1 CHEN Jian1 LIAO Xiang-Cheng1 LAO Xiao-Xia1 HU Chun-Hui1 CHEN Zhi-Ping2* LI-Shan1* 1 Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning , 530021 , Guangxi, 2 School of Public Health，Guangxi Medical University, Nanning , 530021 , Guangxi, China. Abstract： Objective To evaluate the serum carcinoembryonic antigen (CA) 199 in the diagnosis of pancreatic cancer based on evidence-based medicine. Methods The literatures were evaluated according to the evidence-based medicine principles. Main outcomes include design methods, sample screening establishment of control group, *通信作者：陈智平, 联系电话：0771-5358805 E-mail:qinxue919@ 李山，联系电话：0771-5356052 E-mail:lis8858@163.com blind method, and criteria of diagnostic trials. Results 17 documents were included , 16 compared with the gold standard, but did not mention whether use the blind method; Criteria of diagnostic trials such as sensitivity, specificity, likelihood ratio were incomplete., the control of potential bias were not described. As for the literatures sharing the same method , their conclusion did not totally accord with each other .Conclusion There is no evidence to implicate that CA199 is considered an independent predictor of the diagnosis of pancreatic cancer. Key Words: CA199; Pancreatic cancer; Evidence-based Medicine 作者简介：秦雪，女，博士，主任技师，主要从事临床免疫学检验方面的研究，发表论文40余篇。电话：0771-5356052 E-mail:qinxue919@163.com 胰腺癌（car