p75NTR介导神经细胞凋亡研究进展-生命科学.PDFVIP

19 1 Vol. 19, No. 1 2007 2 Chinese Bulletin of Life Sciences Feb., 2007 1004-0374(2007)01-0063-05 p75NTR 1 510080 2 510080 p75NTR Trk p75NTR p75NTR s-p 75NTR proNGF sortilin p75NTR p 7 5 N TR Q255; R322.8A Advance in research on the apoptosis of neuronal cells mediated by p75NTR 1 1 2 LIU Yu , DENG Yubin *, ZHOU Lihua (1 Department of Pathophysiology, Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510080, China; 2 Department of Anatomy, Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510080, China) Abstract: Neurotrophins are essential factors during neuronal development. They promote survival, differen- tiation and myelination of neurons via Trk receptor tyrosine kinases and the p75 neurotrophin receptor. Paradoxically, compare to these “positive” roles, the p75 neurotrophin receptor also ensures some “negative” roles such as apoptosis of neonatal and injured neurons. Until recently, the mechanisms by which the p75 neurotrophin receptor governs these opposing functions have remained elusive. By the identification of new ligands and cytosolic interacting partners, receptor cleavage products and coreceptors such as: s-p75NTR, proNGF and sortilin, some of these mechanisms are now being unraveled. Here, we review recent progress in delineating the molecular networks that enable p75NTR to dictate neuroal apoptosis. Key words: p75NTR; apoptosis; neurons 1p75NTR 151 p75NTR (TNFR) (4 ) (NT) NGF 22