高压静电法制备单分散性的海藻酸钙微胶珠.docxVIP

高压静电法制备单分散性的海藻酸钙微胶珠曲蓓蓓1 ,2 高压静电法制备单分散性的 海藻酸钙微胶珠 曲蓓蓓1 ,2 , 于炜婷1 , 刘袖洞1 , 包德才1 ,2 , 宋晓炎3 , 綦文涛1 ,2 , 马小军1 ( 1 中国科学院大连化学物理研究所 , 辽宁 大连 116023 ; 2 中国科学院研究生院 , 北京 100039 ; 3 浙江大学药学院 , 浙江 杭州 310027) 关键词 : 高压静电场 ; 海藻酸钠 ; 胶珠 ; 单分散 中图分类号 : Q 81 文献标识码 : A 文章编号 : 0438 - 1157 (2005) 08 - 1547 - 05 Prep a ratio n of mo no di sp e r se d calci u m al gi nat e gel bea d s i n hi g h vol t a ge elect ro st atic fiel d Q U Bei bei1 ,2 , YU Weiti ng1 , L IU Xi udo ng1 , B A O Decai1 ,2 , SON G Xiao ya n3 , Q I We nt ao1 ,2 , MA Xiaoj un1 ( 1 L aborat o r y o f B i ome d ic al M ate ri al En g i nee ri n g , D al i a n I ns t i t ute o f Che m ic al P h y s ics , Chi nese A c a de m y o f S ciences , D al i an 116023 , L i aoni n g , Chi n a; 2 Gra d u ate S c hool o f Chi nese A c a de m y o f S cie nces , B ei j i n g 100039 , Chi n a ; 3 Col le ge o f P h a rm ace ut ic al S cie nce , Z he j i a n g U ni ve rs i t y , H an g z hou 310027 , Z he j i a n g , Chi na) A b st ract : In t hi s p ap er , t he eff ect of op eratio n p a ra met e r s o n t he mo no di sp er sit y of calci um2al gi nat e gel bea ds p rep a re d i n high2volt a ge elect ro st atic fiel d we re a nal yzed . The p a ra met e r s i ncl ude d t he app lied po t e ntial ( U ) , t he di st ri b utio n of elect ro st atic fiel d , t he f reque ncy a nd t he f lo w rat e of sol utio n t hro ugh t he capilla r y1 Fur t he r mo re , t he p roce ss i s a nal yze d wit h t he t heo r y of jet brea k2up i n elect ro st atic fiel d1 The re sult sho we d t hat t he mo difie d symmet rical elect ro st atic fiel d wa s mo re a dva nt a geo u s i n p rep a ri ng t he mo no di sp er sed gel bea ds t ha n t he t ra ditio nal met ho d. Mea nw hile , gel ( CV 20 %) a nd st a bilit y wit ho ut a ggregatio n were p ro duced unde r a f reque ncy a nd f lo w rat e of sol utio n t hro ugh t he capilla r y. Key wo r ds : hi gh2volt a g