安维汀抗血管治疗机制.pptVIP

* * * Avastin has demonstrated to increase survival (either PFS or OS) in 6 different tumor types including Ovarian cancer, where we reported two positive phase III studies in 2010 (GOG 218 and ICON-7). Ovarian cancer has been filed in the EU and the US filing is planned for Q4’2011. Last year we also reported that trials in Prostate, Gastric and adjuvant Colon Cancer missed their primary endpoints. * VEGF在肿瘤发生和发展的过程中持续表达1–5 肿瘤发展过程中，VEGF持续表达，甚至在出现次要通路时2,3,6,7 * VEGF VEGF bFGF TGFβ-1 VEGF bFGF TGFβ-1 PLGF VEGF bFGF TGFβ-1 PLGF PD-ECGF VEGF bFGF TGFβ-1 PLGF PD-ECGF Pleiotrophin VEGF持续表达3 1. B