第四章影响药物效应的因素(自学提要).pptVIP

南开大学医学院 张京玲 第四章影响药物效应的因素(自学提要) Chapter 4 目的 了解影响药物作用的因素及合理用药的原则。 Chapter 4 内容 影响药物作用的因素包括有：药物剂型，给药途径，联合用药，相互作用，个体差异，过敏反应，机体生理及病理状态，病原体抗药性及环境因素等。合理用药的原则。 Chapter 4 Individual variation Drug factors Human body factors Drug factors Preparation and Route Bioequivalance Sustained-release preparation Controlled-release preparation Drug factors Drug Interaction Pharmacodynamics Pharmacokinetics Incompatibility Synergism Antagonism Human body Age Male and female Genetic factors Genetic polymorphism Racial differences in drug response Human body Idiocyncrasy Disease state Placebo Changes of resp