文献阅读-缺血-再灌注损伤(下).pdf

Am J Physiol Heart Circ Physiol 285: H579–H588, 2003. First published April 3, 2003; 10.1152/ajpheart.01069.2002. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning Zhi-Qing Zhao, Joel S. Corvera, Michael E. Halkos, Faraz Kerendi, Ning-Ping Wang, Robert A. Guyton, and Jakob Vinten-Johansen Department of Cardiothoracic Surgery, The Carlyle Fraser Heart Center/Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia 30308-2225 Submitted 9 December 2002; accepted in final form 27 March 2003 Zhao, Zhi-Qing, Joel S. Corvera, Michael E. Halkos, tery bypass surgery, organ transplantation, and peripheral Faraz Kerendi, Ning-Ping Wang, Robert A. Guyton, revascularization where reperfusion injury is expressed. and Jakob Vinten-Johansen. Inhibition of myocardial in- infarct size; neutrophils jury by ischemic postconditioning during reperfusion: com- parison with ischemic preconditioning. Am J Physiol Heart Circ Physiol 285: H579–H588, 2003. First published April 3, D 2003; 10.1152/ajpheart.01069.2002.—Ischemic precondition- IN THE LAST TWO DECADES, considerable effort has focused on limiting infarct size and other manifestations of o ing (Pre-con) is an adaptive response triggered by a brief