髓芯减压β-磷酸三钙生物陶瓷棒+颗粒植入术联合前列地尔治疗早期股骨头坏死临床观察.pdf

目 录 摘要 ······························································ ···························· 1 Abstract ······················································ ································ 4 前言 ······························································ ···························· 8 1.材料与方法 ······························································ ··············· 10 2.结果 ····························································· ························ 15 3.讨论 ····························································· ························ 18 4.结论 ······························································ ························ 22 综述：早期股骨头坏死治疗方法研究进展 ········································· 28 附录 ······························································ ··························· 41 攻读学位期间发表文章情况 ···························································· 47 致谢 ······························································ ··························· 48 个人简历 ······························································ ····················· 49 髓芯减压β-磷酸三钙生物陶瓷棒+颗粒植入术联合前列地尔治 疗早期股骨头坏死临床观察 摘要 背景 股骨头坏死（Osteonecrosis of the Femeral Dead, ONFH ）是骨科常见病、多发 病，在早期股骨头坏死保头治疗中，髓芯减压术可减低股骨头髓芯的压力，改善股 骨头血供，从而延缓或者逆转早期股骨头坏死疾病进程，该手术方式广泛应用于目 前临床中。在髓芯减压术的基础上，植入β-磷酸三钙多孔生物陶瓷棒+颗粒，生物 陶瓷棒可以引导股骨头血供，重建股骨头的血供，并且该材料具有良好的骨传导 性、生物相容性、易降解性，植入软骨下骨的陶瓷颗粒降解速度与新骨形成速度相 匹配，形成的新骨力学强度较自身正常骨组织强度高，形成的新骨为软骨下骨提供 了强有力的力学支撑，进而防止股骨头塌陷。前列地尔属于天然前列腺素类物质， 其有效成分为前列腺素 E1 ，是一种血管扩张剂及抑制血小板聚集药物，被广泛用于 周围血管及脑血管疾病的治疗，并取得较满意治疗效果。在本课题的前期研究中发 现在 ARCOⅡ期的患者行髓芯减压生物陶瓷棒+颗粒植入术后，给予前列地尔治疗， 可有效缓解髋关节疼痛，改善髋关