《基础医学各论II》课件：消化系统生理学1.pdfVIP

Gastrointestinal Physiology Liang Huawei, Ph.D. E-mail: liang.huawei@ Anatomy of gastrointestinal system GI tract Accessory organs Functions of gastrointestinal system Movement: propels food through the digestive system Secretion: release of digestive juices in response to a specific stimulus Digestion: breakdown of food into molecular components small enough to cross the plasma membrane Absorption : passage of the molecules into the bodys interior and their passage throughout the body Elimination: removal of undigested food and wastes Physiological properties of gastrointestinal smooth muscle 消化道平滑肌的特性 General properties (一般特性) Low excitability High distensibility (扩张性) Tonic contraction Autorhythmicity High sensitivity to temperature, stretch and chemical stimulation Electrophysiological properties (电生理 特性) Resting membrane potential −50 ~ −60 mV Ionic basis + + Em (selective membrane permeability to K , Na , Cl− and Ca2+) + + Electrogenic Na -K pump Slow wave (慢波电位) / Basic electrical rhythm (BER, 基本电节律) The spontaneous rhythmic, subthreshold depolarizations of the cell membrane (slow wave) of the gastrointestinal tract Initiated in the interstitial cells of Cajal (ICC) (pace maker cell) Santiago Ramon Y Cajal He and Camillo Golgi received the Nobel Prize in 1906 for introduction of the silver-chromate （铬酸银）stain Slow wave / Basic electrical rhythm (BER) Intensity: 10~15 mV Frequency: 3~12 cpm Ionic mechanism + +