《基础医学各论II》课件：消化系统生理学2.pdfVIP

Gastrointestinal Physiology (2) Liang Huawei, Ph.D. E-mail: liang.huawei@ Digestion in the small intestine 小肠内消化 Pancreatic secretion Pancreatic juice 胰液 pH 7.8~8.4 ~1500 ml/day Isosmotic Components Pancreatic digestive enzymes （胰消化酶） Sodium bicarbonate （碳酸氢钠） Secretion of bicarbonate ions Secreted by the epithelial cells of the ductules (小叶导管) and ducts that lead from acini (腺泡) Up to 145mmol/L in pancreatic juice (5 times that in the plasma) Neutralizing acid entering the duodenum from the stomach Secretion of pancreatic digestive enzymes Pancreatic amylase (胰淀粉酶) Pancreatic lipase (胰脂肪酶) Fat Cholesterol esterase (胆固醇酯酶) Phospholipase (磷脂酶) Trypsinogen (胰蛋白酶原) Chymotrypsinogen (糜蛋白酶原) Procarboxypolypeptidase (羧基肽酶) Starches Pancreatic amylase Maltose (麦芽糖) and 3 to 9 glucose polymers Trypsin Inhibitor (胰蛋白酶抑制物) Inhibits the activity of trypsin and thus guards against the possible activation of trypsin and the subsequent autodigestion of the pancreas Regulation of pancreatic secretion Basic stimuli that cause pancreatic secretion Ach Cholecystokinin （胆囊收缩素/促胰酶素） Secreted by I cells Stimulates the acinar cells to secrete large amounts of enzymes Secretin （促胰液素） Released by S cells Acts primarily on the duct cells to stimulate the secretion of a large volume of solution with a high HCO3− (bicarbonate) concentration Phases of pancreatic secretion Cephalic Phase An autonomic reflex response to stimulation of olfactory and taste receptors Stimulation of the acinar cells by ‘long’ parasympathetic pathway