2008七年制生化B答案.doc

PAGE PAGE 1 2006级临床医学、药学、口腔七年制专业生物化学试题B卷答案 一．名词解释：（每题 4分，共 20 分）1. Motif：group of secondary structural elements that fold to near each other in space and have special functions, such as αα motif, β α β motif, zinc finger motif. Some motifs consist of only a few conserved functionally important AAs rather than super-secondary structures. e.g. RGD (Arg-Gly-Asp ) motif 2. Covalent modification：the structure and activity of many enzymes can be altered reversibly through covalent modification by another enzyme.The most common modification is phosphorylation /dephosphorylation, which is reversible addition and removal of a phosphate at -OH group of Ser, Thr and Tyr. 3. b-oxidation of fatty acids：Inside of the mitochondrion; fatty acyl-CoAs are oxidized in a series of cycles that each cycle release a two-carbon fragment, in the form of acetyl-CoA; Each cycle involves four reactions-dehydrogenation, hydration, dehydrogenation, and thiolytic cleavage. 4. Oxidative phosphorylation：In the mitochondrion, The process of the enzymatic phosphorylation of ADP to ATP coupled to electron transfer from a substrate to molecular oxygen is termed Oxidative phosporylation. 5. Putrefaction of protein：After the absorption of most of protein, intestinal bacterial activity act on the residue passed into the large intestine, that is called putrefaction of protein.Most of the producer of the putrefaction of protein are harmful to human beings, for example: amine, ammonia, phenol, indole and sulfureted hydrogen. A型题1. D 2. C 3. A 4. C 5. D 6. A 7. D 8. B 9. C 10. D 11. C 12. B 13. C 14. A 15. D 16. E 17. C 18. E 19. A 20. A X型题21. ACD 22. ABCD 23. ABCD 24. ABCD 25. ACD 26. ADE 27. BCE 28. BD 29. BCDE 30. AC 31. ABDE 32. ACDE 33. ABCDE 34. ABCDE 35. ABCD 36. ABDE 37. AB 38. AB 39. BDE 40. ACD 1. 丙氨酸转氨（GPT）→Glu＋丙酮酸（1）； 丙酮酸→草酰乙酸→PEP，1）→异生，葡萄糖。（3）2）→乙酰CoA→TAC氧化。（2） 3）脱下氢，呼吸链，H2O， ATP。（2） 2．单核-吞嗜细胞：衰老红细胞血红素→胆绿素→胆红素；（1） 血，清蛋白结合运输；（1） 肝摄取，配体蛋白转运，结合G