脑益智方联合康复训练治疗肌张力低下型脑性瘫痪临床观察.docVIP

脑益智方联合康复训练治疗肌张力低下 型脑性瘫痪临床观察 孙进王君 林晓芬 谢冰 伍芳 湖北省恩施州中心医院康复医学科 摘要： 冃的：观察醒脑益智方联合康复训练治疗肌张力低下型脑性瘫痪的临床疗效，并 分析其机制。方法:随机选取于2014年1月至2015年12月恩施州中心医院康复 门诊及住院的才岁肌张力低下型脑性瘫痪患儿120例，按随机数字表法随机分 为观察组和康复组，每组60例，同时选取20例同期同院体检科体检的正常健康 患儿作为对照组。康复组予以康复训练，观察组予以康复训练结合醒脑益智方治 疗。同时对各组患者进行的GMFM量表的评估，测定其肌力的变化，并抽取血液 测定转化生长因子B1和BDNF,比较各组数据的统计差异并分析其临床疗效。 结果:经治疗后，观察组与康复组治疗后的GMFM、肌力与TGF-(3 1均较治疗前明 显提高(P0. 05) , BDNF降低(P0. 05)，且观察组治疗后与对照组比较较，差 异无统计学意义(P0. 05)。结论:醒脑益智方联合康复训练可以有效改善治疗 肌张力低下型脑性瘫痪临床症状，改善其肌力，提高患儿的生活能力水平，值 得推广使用。 关键词： 醒脑益智方;肌张力低下型;脑性瘫痪;神经重塑;转化牛长因了 0 1; 作者简介：孙进(1985. 08-),男，本科，住院医师，研究方向：中西医结合治 疗神经内、外科脑出血、脑梗死等，E-mai 1 :ml3872713536_1 @163. com 收稿日期:2017-07-05 基金：湖北省卫生和计划生育委员会科研项目(WJ2015MB115) Effects of Xingnao Yizhi Fang Combined with Rehabilitation Training on Children with Cerebral Palsy Due to Dystonia and its Effect on Transforming Grow th Fac tor Beta 1 and Nerve Remodeling in Children Sun Jin Wan￡ Jun Lin Xiaofen Xie Bing Wu Fang Department of Rehabilitotion and Medicine, The Central Hospital of Enshi Prefecture, Hubei Proucnce; Abstract： Ob jecti ve: To observe the cl inical cura.tive effect of Xingnao Yizhi Fang combined with rehab i 1 i tat ion training in the treatment of aton ic cerebral palsy, and to analyze its mechanism. Met hods: A total of 120 cases of children with cerebral palsy due to dystonia aging 2-6 years old who were treated in outpatient department and hospitalization department in our hospitol from January 2014 to December 2015 were seiected and divided into treatment group and rehabilitation group with 60 cases in each. And 20 cases of healthy children from physical examination department of our hospital were selected as control group. The rehabilitation group was given rehabilitation training, and the treatment group was given rehabilitation training combined wi th Xingnao Yi zhi decoct ion. At the same time, the GMFM scale of each group was evaluated, and the changes of muscle strength were measured. The blood samples were taken to determine TGF-beta 1 and BDNF. The