肿瘤代谢调节疗法.pptVIP

* Mechanisms of anti‐oncogenic effect of metformin. AMPK, adenosine 5′‐mono‐phosphate‐activated protein kinase; HER2, epithelial growth factor receptor 2; IGF, insulin‐like growth factor; IGF‐1R, insulin‐like growth factor 1; IR, insulin receptor; mTOR, mammalian target of rapamycin; PI3K, phosphinositide 3‐kinase; TSC2, tuberous sclerosis complex 2; VEGF, vascular endothelial growth factor. Adapted from Jalving et al.87 with permission. * * 转移性乳腺癌患者原发灶及转移灶细胞表面葡萄糖调节蛋白78表达升高cell surface–localized glucoseregulated protein 78 (GRP78) * * * 肿瘤细胞的糖酵解能力是正常细胞的20~30倍，糖酵解强度与肿瘤生长速度和侵袭性密切相关。肿瘤细胞中多至50%的ATP来源于糖酵解途径。结肠癌肿瘤组织较外周组织糖摄取增加30倍，乳酸释放增加40倍。这种代谢特点使得葡萄糖成为肿瘤代谢调节治疗的重要靶点。 * * 脂肪代谢:肿瘤病人的脂肪组织动员加快，脂肪储备消耗，表现为高血脂症。同时由于氧化磷酸化过程分离，使能量消耗迸一步增加，脂肪组织的消耗也是肿瘤病人恶病质的主要原因之一。 * * 脂肪代谢:肿瘤病人的脂肪组织动员加快，脂肪储备消耗，表现为高血脂症。同时由于氧化磷酸化过程分离，使能量消耗迸一步增加，脂肪组织的消耗也是肿瘤病人恶病质的主要原因之一。 * * 尝粪忧心 　　 南齐庾(于)黔(qian钱)娄(楼)，为孱(缠)陵令。到县未旬日，忽心惊汗流，即弃官归。时父疾始二日，医曰：“欲知瘥剧，但尝粪苦则佳。”黔娄尝之甜，心甚忧之。至夕，稽颡北辰求以身代父死。 　　 庾黔娄，南齐高士，任孱陵县令。赴任不满十天，忽觉心惊流汗，预感家中有事，当即辞官返乡。回到家中，知父亲已病重两日。医生嘱咐说：“要知道病情吉凶，只要尝一尝病人粪便的味道，味苦就好。” 黔娄于是就去尝父亲的粪便，发现味甜，内心十分忧虑，夜里跪拜北斗星，乞求以身代父去死。几天后父亲死去，黔娄安葬了父亲，并守制三年。 * 转移性乳腺癌患者原发灶及转移灶细胞表面葡萄糖调节蛋白78表达升高cell surface–localized glucoseregulated protein 78 (GRP78) * * 转移性乳腺癌患者原发灶及转移灶细胞表面葡萄糖调节蛋白78表达升高cell surface–localized glucoseregulated protein 78 (GRP78) * * 转移性乳腺癌患者原发灶及转移灶细胞表面葡萄糖调节蛋白78表达升高cell surface–localized glucoseregulated protein 78 (GRP78) * * 转移性乳腺癌患者原发灶及转移灶细胞表面葡萄糖调节蛋白78表达升高cell surface–localized glucoseregulated protein 78 (GRP78) * * MCF10A PI3Kα (+/+) and MCF10A PI3Kα (H1047R/+) cells were grown for 120 hours in media containing 25 mM glucose or without glucose as indicated. All media contained 2 mM glutamine. Additionally, cells grown without glucose were supplemented with either 0.5 mM fructose (+ fruct), 10 mM galactose (+ galact), fatty acid cell culture supplement (+FA) or 0.1 mM aspartic acid (+AA). Cell growth was assessed using SRB. MCF10A PI3Kα isogenic cells (+/+, H1047R/+ and E545K/+) and HCT116 isogeni