CyclinE2和Survivin在急性白血病的表达及其相关性.docVIP

CyclinE2和Survivin在急性白血病的表达及其相关性 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：CyclinE2和Survivin在急性白血病的表达及其相关性 1 文2：survivin和环氧化酶2在膀胱移行细胞癌组织中的表达及其相关性 12 1 材料与方法 12 2 结 果 14 3 讨 论 15 参考文摘引言： 17 原创性声明（模板） 19 文章致谢（模板） 19 正文 CyclinE2和Survivin在急性白血病的表达及其相关性 文1：CyclinE2和Survivin在急性白血病的表达及其相关性 As a malignant hemophaty，acute leukemia (AL)，especially，acute lymphocytic leukemia （ALL） underwent a high relapse rate and a short disease-free survival (DFS)，in spite of the improvement in clinical outcome benefited from the development of hematopoietic stem cell traplantation (HSCT) and chemical relapse and prolonging DFS still is the focus of AL residual disease (MRD) became an effective indication for the foundation of post-remission therapy regulation since the routine morphological examination of the peripheral blood and bone marrow sample from the remission patient was the fusion gene such as AML1/MTG8 and PML/RARα as MRD marker，was only used in M2，M3，so it is valuable to search another new MRD marker for the other hand，RNA interference (RNAi) as a new and prospective gene therapy for cancer has become a new focus of the study of AL therapy［1］.Searching for an effective new target for a tumor-specific RNAi is worth developing for leukemia ，as a type of G1 cyclin，cyclin E2 was found out to be the potential marker of tumo since it presented a positive expression in the cell lines of solid tumo and a negative expression in proliferating normal cells［2］.However，there has been no report on its expression and role in order to find out the role of cyclin E2 in the progression and clinical outcome of Al patients，revee tracription polymerase chain reaction (RT-PCR) is adopted to test the expression of cyclin E2 and survivin mRNA in 84 adult patients with AL，20 normal peo as controls and leukemia cell line ，we investigated the relatiohip between the expression of cyclin E2 and the clinical progression of AL study of cyclin E2 can provide a preliminary theoretical