TNFα基因单核苷酸多态性与HBV感染结局医学.docVIP

TNFα基因单核苷酸多态性与HBV感染结局医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：TNFα基因单核苷酸多态性与HBV感染结局医学 1 1 对象与方法 3 2 结果 3 22 TNF-α启动子区基因多态性与HBV感染结局的关系 4 3 讨论 5 文2：淋巴毒素α基因单核苷酸多态性与脑梗塞的相关性研究医学 6 1研究对象和方法 6 参考文摘引言： 9 原创性声明（模板） 10 文章致谢（模板） 11 正文 TNFα基因单核苷酸多态性与HBV感染结局医学 文1：TNFα基因单核苷酸多态性与HBV感染结局医学 Relatiohip between polymorphisms of TNF-α gene promoter region and HBV infection outcome Abstract： Objective To determine whenther -238G/A,-857T/C and -863C/A polymorphisms of tumor necrosis factor-alphya (TNF-α) gene promoter were associated with outcomes of hepatitis B virus (HBV) A total of 244 HBV self-limited infected subjects,212 asymptomatic HBsAg carrie (HBsAg carrie) and 391 chronic hepatitis B (HB) patients were recruited to conduct a case-control α-238G/A,-857C/T and -863C/A gene promoter polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results The frequency of -238 allele A in self-limited individuals was %,significantly lower than % in chronic HB patients and % in HBsAg carrie (P= and P=), frequency of TNF-α-857 allele C in chronic HB patients was %,significantly higher than % in HBsAg carrie and % in self-limited individuals (P= and P=), frequency of TNF-α-863 allele A in chronic HB group was %,significantly higher than % in HBsAg carrie (P=).Multiple logistic regression analyses indicated an increased risk of chronic HB associated with TNF-α-238GA and -857CC after gender and age adjusting (OR=,P=;OR=,P=),and HBsAg carrie with -857CC significantly increasing risk of chronic HB associated with TNF-α -238GA and -857CC after gender and age adjusting (OR=,P=;OR=,P=),an HBsAg carrie with -857CC significantly increasing risk of chronic HB(OR=,P=),and -238GA associated with and increasing risk of HBsAg carrie (OR=,P=).Conclusion TNF-α promoter polymorphism is probably an important risk factor of the influence of outcome of HBV infection. Key words： hepatitis B;tumor nectosis factor-alpha(TNF-α)gen