急性白血病化疗前后检测血清α1AG的意义临床医学.docVIP

急性白血病化疗前后检测血清α1AG的意义临床医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：急性白血病化疗前后检测血清α1AG的意义临床医学 1 1 材料和方法 3 1．1 研究对象 3 1．1．1 急性白血病组 3 1．1．2 正常对照组 3 1．2 方法 3 1．2．1 标本采集 3 1．2．2 血清α1AG检测 4 1．2．3 统计学处理 4 2 结果 4 3 讨论 5 文2：肝炎肝硬化病人血清AG比值的意义临床医学 6 1资料与方法 6 参考文摘引言： 8 原创性声明（模板） 9 文章致谢（模板） 9 正文 急性白血病化疗前后检测血清α1AG的意义临床医学 文1：急性白血病化疗前后检测血清α1AG的意义临床医学 Abstract： Objective To study serum level of α1acid glycoprotein (α1AG) in the patients with acute leukemia (AL) and its clinical A total of 51 patients with AL before treatment and 11 relapsing patients were selected. Their serum level of α1AG was measured and compared with that of normal controls. Results Serum level of α1AG was significantly higher in the patients with AL before treatment and in the relapsing patients than in the normal controls (t=, P). The serum α1AG level of 15 complete remission (CR) patients decreased significfintly, and the difference between CR group and the normal group was not significant (t=,P). The serum α1AG level of refractory acute lymphocyte leukemia (ALL) patients were significantly higher than that of the remission group, and the difference between them was significant (t=,P). The serum α1AG level of refractory acute myelogenous leukemia (AML) patients was significantly higher than that of the remission group, and the difference between them was significant (t=, P). Conclusion Serum α1AG can be used for detecting clinical features and evaluating curative effect in the patients with AL. Key words： α1acid glycoprotein; leukemia; acute 血清α1酸性糖蛋白(α1acid glycoprotein)是由肝脏合成，在血清中含糖量最高、酸性最强的单链糖蛋白，是一种急性时相反映蛋白。正常人血清中含量较低，但在感染急性期和恶性肿瘤等病理状态下其浓度明显升高，并与患者的 治疗 进程有关。本研究对51例急性白血病初治患者、11例复发患者血清α1AG的水平进行了检测，以探讨白血病患者血清α1AG的水平变化与疗效的关系。 1 材料和方法 1．1 研究对象 1．1．1 急性白血病组 51例急性白血病初诊未治患者及11例复发患者均为我院血液科2004年4月—2005年9月间的门诊及住院患者，其中男35例，女27例，年龄7~65岁。急性淋巴细胞白血病(ALL)33例，其中27例为初诊未治患者，6例为复发患者；急性髓细胞性白血病（AML）29例，其中24例为初诊未治患者，5例为复发患者； 经随访51例急性白血病初诊未治患者中有16例诊断为难治型白血病(ALL9例，AML