血清可溶性CD30预测早期急性排异反应在肾移植受者术后.docVIP

血清可溶性CD30预测早期急性排异反应在肾移植受者术后 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：血清可溶性CD30预测早期急性排异反应在肾移植受者术后 1 0 引言 2 1 对象和方法 3 2 结果 4 3 讨论 6 文2：点征在预测早期颅内血肿扩大中的应用 8 1资料与方法 8 参考文摘引言： 13 原创性声明（模板） 14 文章致谢（模板） 14 正文 血清可溶性CD30预测早期急性排异反应在肾移植受者术后 文1：血清可溶性CD30预测早期急性排异反应在肾移植受者术后 【Abstract】 AIM: To evaluate the feasibility of posttraplantation serum soluble CD30 (sCD30) for prediction of acute graft rejection. METHODS: Two hundred and thirtyone patients were included into the study, whose serum levels of sCD30 were detected by ELISA before and after traplantation. Then, they were divided into three groups according to the clinical features one month posttraplantation: acute rejection group (AR,n=49), delayed graft function group (DGF,n=11) and uncomplicated coue group (UC,n=171). RESULTS: Significant decrease of sCD30 was detected on day 5 and 10 posttraplantation respectively［ (178±79） U/mL vs (52±30) U/mL, (9±5) U/mL,P］. Compared with Group UC and DGF, patients of Group AR had higher sCD30 values on day 5 posttraplantation ［(92±27) U/mL vs (41±20) U/mL and (48±18) U/mL, P)］. However, sCD30 levels were not different between three groups before traplantation and on day 10 posttraplantation (P). Receiver operating characteristic (ROC) curve demotrated that sCD30 level on day5 posttraplantation differentiated patients who subsequently suffered acute allograft rejection from othe (area under ROC curve ). According to ROC curve, 65 U/mL was the optimal operational cutoff level to predict impending graft rejection (specificity=%, seitivity=%). CONCLUSION: Measurement of sCD30 on 5 day posttraplantation might offer a noninvasive mea to recognize patients at risk of impending acute graft rejection during early posttraplantation period. 【Keywords】 soluble CD30; graft rejection; seitivity and specificity; kidney traplantation 0 引言 新型免疫抑制剂的出现大大降低了急性排异反应的发生率，但是，急性排异反应仍旧是引起早期移植肾失功和慢性移植肾肾病的主要原因［1-2］. 尽管移植肾穿刺活检仍旧是目前诊断急性排异反应唯一可靠的方法，但是在移植肾穿刺活检诊断排异反应的同时，排异反应所造成的移植