兔坠落式颅脑减速伤的实验研究.docVIP

兔坠落式颅脑减速伤的实验研究 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：兔坠落式颅脑减速伤的实验研究 1 1 致伤装置设计 3 2 实验动物及分组 3 3 动物致伤 3 4 伤情观察 4 1 减速伤致伤高速摄像观察 4 2 伤情观察 5 文2：兔椎间失稳软骨终板退变的实验研究 8 1 材料与方法 9 2 实验结果 11 3 讨论 11 参考文摘引言： 13 原创性声明（模板） 15 文章致谢（模板） 15 正文 兔坠落式颅脑减速伤的实验研究 文1：兔坠落式颅脑减速伤的实验研究 Abstract： Objective To build the animal model of decelerationinduced brain injury due to falling and study its injury The decelerationinduced brain injury was produced in rabbits by utilizing an impactor setup coisting of four steels for sliding,a sled,a base,an impactor platform and a supporting of 55 rabbits were in the control group,while 45 rabbits in the experimental group were divided into 3 groups averagely at random according to the falling height： in group Ⅰ, in group Ⅱ,7m in group Ⅲ.The rabbits were fixed backlying on the sled and fell from varying process of injuryinducing was recorded with high speed characteristics of decelerationinduced brain injury was investigated from rabbits behavior after injury,CT image,gross anatomy and pathophysiological Nine rabbits survived in group Ⅰ and 6 in group Ⅱ within 4 hou after injury,and all rabbits died at once after injury in group Ⅲ.No brain injury was observed in group Ⅰ.There was skull fracture,brain contusion,subdural hemorrhage,contrecoup injury and slight parenchyma hemorrhage in some rabbits in group Ⅱ.There was skull fracture,brain contusion,subdural hemorrhage,contrecoup injury and parenchyma hemorrhage in all rabbits in group Ⅲ.The main pathophysiological changes of decelerationinduced brain injury was hemorrhagic brain The severity of injury was affected by the falling injury could be observed obviously in severe decelerationinduced brain injury. Key words：brain injury;decelerationinduced injury;biomechanics;rabbits 颅脑减速伤是运动着的头颅突然碰撞在外物上，迫使其瞬间由动态转为静态，因此而造成的脑损伤[1]。颅脑减速伤在 交通 事故、坠落事故中较常见[2-4]，且损伤重。近年来，虽然也有关于颅脑减速伤的临床报道[5，6]和实验研究[7，8]，但关于颅脑减速伤的实验研究鲜有报道，对于颅脑减速伤的伤情特点及生物力学致伤机制还不十分清楚。本文拟研制减速伤致伤装置，并复制兔