P16蛋白检测在子宫颈腺癌和子宫内膜腺癌鉴别诊断中的意义临床医学.docVIP

P16蛋白检测在子宫颈腺癌和子宫内膜腺癌鉴别诊断中的意义临床医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：P16蛋白检测在子宫颈腺癌和子宫内膜腺癌鉴别诊断中的意义临床医学 1 1.材料和方法 3 2 结果 4 3 讨论 6 文2：尿液转铁蛋白微白蛋白检测在糖尿病肾病早期诊断中的意义临床医学 7 1 对象与方法 8 2 结果 9 3 讨论 9 参考文摘引言： 10 原创性声明（模板） 12 文章致谢（模板） 12 正文 P16蛋白检测在子宫颈腺癌和子宫内膜腺癌鉴别诊断中的意义临床医学 文1：P16蛋白检测在子宫颈腺癌和子宫内膜腺癌鉴别诊断中的意义临床医学 【Abstract】 Objective:TObjectives Observation of p16 protein in cervical adenocarcinoma and endometrial cancer in the differential diagnosis of significance. Also part of the guideline on early cases whether the fertility preservation. Methods SP with Immunohistochemistry assay for the detection of cervical adenocarcinoma and 40 examples of 73 cases of endometrial carcinoma p16, p53, ER and PR of the expression. Results (1) the p16 in 40 examples of cervical adenocarcinoma in 37 cases (%) is diffuse and positive, in 73 cases of endometrial carcinoma in 28 patients (%) is of positive. (2) in cervical adenocarcinoma in p53, ER, PR positive expression of various % and % and %, while in endometrial cancer in p53 % overexpression, Hormone receptor ER, PR in endometrial cancer respectively % and % expression. In cervical adenocarcinoma p16 protein in the diffuse nuclear and cytoplasmic-positive, and histological forms resemble endometrial carcinoma irregular of positive, and the overall strength is low . In cervical adenocarcinoma p16 protein displayed prevalent, the strength of expression in to, and histological forms resemble endometrial carcinoma is the weaker of positive. P16 protein p53 protein detection at the joint, hormone receptor ER, PR will not only identify cervical adenocarcinoma and endometrial cancer, can also be used for uterine serous carcinoma and endometrial cancer diagnosis. Conlusio Coultation on biopsy or scraping of uterine cancer samples, selection of p16 protein detection can be used as an auxiliary immunocytochemistry to identification of cervical adenocarcinoma and endometrial cancer. 【Key words】Carcinoma of cervix ute