老年颈动脉硬化患者血清黏附分子的研究.docVIP

老年颈动脉硬化患者血清黏附分子的研究 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：老年颈动脉硬化患者血清黏附分子的研究 1 1 对象与方法 3 2 结 果 4 3 讨 论 4 文2：老年颈动脉硬化患者血清炎症因子中医证型的关系 6 1 临床资料 7 2 方法 7 3 结果 9 4 讨论 9 参考文摘引言： 10 原创性声明（模板） 12 文章致谢（模板） 12 正文 老年颈动脉硬化患者血清黏附分子的研究 文1：老年颈动脉硬化患者血清黏附分子的研究 【Abstract】 Objective To study the relatiohip between the levels of serum intercelluar adheion molecule1 (ICAM1), vascular cell adhesion molecular1 (VCAM1), Eselectin and Pselectin from aged carotid artery atherosclerosis patients with carotid artery atherosclerosis. Methods Blood sample were collected from 176 aged carotid artery atherosclerosis patients. The concentratio of ICAM1, VCAM1, Eselectin and Pselectin were tested by mea of ELISA. In the meantime, all carotid arteries of 176 cases were examined with color Doppler ultrasound. The subjects were divided into 2 groups according to the severity of lesion of carotid artery. The concentratio of inflammatory facto were compared in different groups. Results Compared with control group, the levels of inflammatory facto in groups of carotid atherosclerosis and carotid plaques were higher; the levels of ICAM1 and Pselectin in carotid plaques were higher than those of carotid atherosclerosis (P). And there were positive relatiohip between the degree of carotid atherosclerosis and the levels of serum inflammatory facto (P). Conclusio The level of serum inflammatory facto of aged carotid artery atherosclerosis patients could reflect the degree of carotid artery atherosclerosis. 【Key words】 Carotid artery atherosclerosis; Intercelluar adheion molecule1; Vascular cell adhesion molecular1; Eselectin; 目前普遍认为颈动脉硬化的发生是由于致伤因素和血管反应之间复杂的相互作用的结果。严重颈动脉硬化的患者即使在药物的干预下，脑卒中的发生率仍为15%～20%，提示颈动脉硬化在脑梗死的发生中起重要作用〔1〕。颈动脉硬化过程中，多种黏附分子介导的细胞间的黏附在其发生 发展 中起了极其重要的作用，而循环中血清黏附分子的水平则反映了这一炎症反应状态〔2〕。本研究通过对老年颈动脉硬化患者血清内皮细胞黏附分子(ICAM1)、血管细胞黏附分子1(VCAM1)、E选择素和P选择素等黏附分子水平及颈动脉超声检查，探讨黏附分子与老年颈动脉硬化的关系。 1 对象与方法 观察对象 全部患者来自2005年9月至2008年4月间，本院就诊的颈动脉硬化患者，共176例，其中男性109例、年龄