不同联合用药方案治疗老年单纯收缩期高血压的对照研究.docVIP

不同联合用药方案治疗老年单纯收缩期高血压的对照研究 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：不同联合用药方案治疗老年单纯收缩期高血压的对照研究 1 1 资料与方法 3 2 结 果 4 3 讨 论 5 文2：生物反馈疗法治疗老年单纯收缩期高血压的临床疗效 6 1资料与方法 6 1．1一般资料 6 1．2方法 7 1．3观察方法及指标 7 1．4统计学方法 7 参考文摘引言： 8 原创性声明（模板） 10 文章致谢（模板） 10 正文 不同联合用药方案治疗老年单纯收缩期高血压的对照研究 文1：不同联合用药方案治疗老年单纯收缩期高血压的对照研究 【Abstract】 Objective To compare the efficacy and safety of two treatments of antihyperteion (general hypoteor and small dose of general hypoteor added with mononitrate) for senile patients with isolated systolic hyperteion (ISH). Methods 176 cases with mildtomoderate ISH were divided into two groups randomly. All of the patients in the united group were given captopril 25 mg, hydrochlorothiazide mg and isosorbide mononitrate 40 mg per day in the morning. And the patients in the normal group were given captopril 25 mg twice a day and hydrochlorothiazide 25 mg once a day. The coue of the treatment was 8 weeks. Blood pressure and biochemical indicator before and after the medicine were The effect on systolic pressure and diastolic pressure was obviously in the united group. And the general efficacy of the united group and the normal group were % and % separately, and there was obvious difference between the two groups (P). There was no obvious difference in heart rate and biochemical indicator between the two groups (P). Conclusio The therapy of small dose of captopril, isosorbide mononitrate and hydrochlorothiazide once in the morning can efficiently decrease the blood pressure of senile patients with mildtomoderate ISH. The therapeutic effect is doubled by double doses of captopril and hydrochlorothiazide, which has no bad effect on metabolism. 【Key words】 Aged people; Isolated systolic hyperteion; Dyazide 老年单纯收缩期高血压(ISH)的发病机制与青年人不同，患者的外周血管阻力只有临界性的升高，主要是由于大动脉僵硬所导致〔1，2〕，而现有抗高血压药物主要针对降低周围血管阻力，因而在降低收缩压(SBP)的同时，容易使舒张压(DBP)过低，脉压(PP)增宽，从而造成新的心、脑血管事件危险性。目前认为，在降低大动脉僵硬度及相关心脏效应的药物中，利尿剂、硝酸酯类药物、肾素血管紧张素醛固酮系统(RAAS)抑制剂是最常用的〔3〕。为使此类患者克服常规降压药治疗抵抗，本研