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Today′s discussion Key elements of Life Cycle Management Thoughts on how to organize for LCM Key issues 第三十页,共四十一页。 Design principles Drive life cycle management around the major planning events (early on milestones and later in annual planning cycle) Create clear roles and responsibilities between global and markets Document life cycle management thinking in a simple document that potentially is broader than the business plan document 第三十一页,共四十一页。 Focus areas and early recommendations Clarify decision-making around LCM Make LCM-plan an integral part of tollgate decisions Make LCM planning part of annual portfolio management process Define roles and responsibilities Define who has what responsibilities Define the company life cycle plan Upgrade the LCM-plan to a real annual strategy document for post launch Define the company LCM-plan (aligned with markets) Organize for creation and management of the LCM-plan Clarify leadership – commercial versus technical Create a standing/recurring LCM sub-team including key markets Make LCM a priority in annual planning Define the role in annual planning Define the company minimum standard Link budgets to LCM planning 第三十二页,共四十一页。 Life cycle thinking should be part of the early development tollgate decisions Choice of first indication Target label assessment Preliminary target Target label evolution over time Patent/IP strategy Choice of CD and backup Rough life cycle vision Future development activities Evolution of positioning Updated target label assessment Staircase Development project plan for proposed scenario Scope Scale Investment for speed Updated LCM plan Agreed vision with markets Future development initiatives Evolution of positioning Future marketing initiatives Updated development project plan for proposed scenario Ensure supply Updated target label assessment Final “launch” target label Updated LCM plan ILLUSTRATIVE Pre-CD CD nomination Proof of concept Approval to launch 第三十三页,共四十一页。 A good LCM plan considers

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